Results 61 to 70 of about 16,682,348 (303)

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Pan-Africa passport to open up borders

open access: yesAfrica Renewal, 2016
The image of Rwandan President Paul Kagame and Chadian President Idriss Deby proudly holding the first two copies of the newly launched pan-African passport at the African Union (AU) summit in the Rwandan capital Kigali this month marked the type of historic moment rarely seen at such gatherings, where outcomes are often measured in declarations or ...
openaire   +1 more source

Effects of seat pan and pelvis angles on the occupant response in a reclined position during a frontal crash.

open access: yesPLoS ONE, 2021
Current highly automated vehicle concepts include reclined seat layouts that could allow occupants to relax during the drive. The main objective of this study was to investigate the effects of seat pan and pelvis angles on the kinematics and injury risk ...
Cyrille Grébonval   +4 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

PAN-00011095 - iron open socketed axe

open access: yes, 2020
This find is registered at Portable Antiquities of the Netherlands with number PAN ...
Portable Antiquities of the Netherlands, DataCurator
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Archiwum Danych Jakościowych przy IFiS PAN

open access: yes, 2019
This text contains information about the Qualitative Data Archive at the Institute of Philosophy and Sociology PAS (QDA) [Archiwum Danych Jakościowych przy IFiS PAN — ADJ; adj.ifispan.pl], which collects and digitalizes databases from a broad range of ...
, Zespół Archiwum Danych Jakościowych przy IFiS PAN
core   +1 more source

Pan-Genome Analysis of Delftia tsuruhatensis Reveals Important Traits Concerning the Genetic Diversity, Pathogenicity, and Biotechnological Properties of the Species

open access: yesMicrobiology Spectrum, 2022
Delftia tsuruhatensis strains have long been known to promote plant growth and biological control. Recently, it has become an emerging opportunistic pathogen in humans.
Zhiqiu Yin   +12 more
doaj   +1 more source

Developing a Pan-European Open Science Training Landscape

open access: yesABI Technik, 2023
Abstract In an environment designed to increasingly enable Open Science, not all researchers and research supporting units have the required competences. Moreover, there is a lack of clear data professionals’ profiles and corresponding career paths, and a high degree of fragmentation in training resources.
Dr. Paolo Budroni   +3 more
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

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