Results 91 to 100 of about 421,085 (302)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Peer review and publication delay

open access: yesPharmacy Practice, 2019
Selecting peer reviewers is a crucial stage of the editorial process that ensures the quality of scholarly publications. An alternative to selecting peer reviewers from data bases created with expressions of interest of volunteers consists in ...
Fernandez-Llimos F   +1 more
doaj   +1 more source

Peer Review Week 2021: Preprints Meet Open Peer Review

open access: yes, 2021
<em> <strong> Embracing identity in Peer Review </strong> </em> The COVID-19 pandemic has brought into stark focus is the importance of both a speedy dissemination of research (something our participation in the C19 Rapid Review Consortium has tried to tackle), and the need to be able to trust the validity of this information.
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Open peer review: un esperimento

open access: yesBollettino Telematico di Filosofia Politica, 2012
Come abbiamo scritto anche su queste pagine, la revisione paritaria tradizionale è da tempo in discussione. Perché dei giudici anonimi, scelti segretamente dalla direzione di una rivista, dovrebbero garantire una valutazione accurata e imparziale dei ...
Maria Chiara Pievatolo
doaj  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Open science publishing practices can break commercial publishers’ dominant position in the dissemination of scientific results

open access: yesDutch Journal of Applied Linguistics
In this response to Diamond is a scientist's best friend, Pascal Braak discusses open science practices from a bibliographic perspective and among other things, sketches how a fully open and transparent knowledge generation process may break the power ...
Pascal Braak
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

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