Results 101 to 110 of about 27,427,486 (239)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
In this response to Diamond is a scientist's best friend, Pascal Braak discusses open science practices from a bibliographic perspective and among other things, sketches how a fully open and transparent knowledge generation process may break the power ...
Pascal Braak
doaj +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Open peer review: un esperimento
Come abbiamo scritto anche su queste pagine, la revisione paritaria tradizionale è da tempo in discussione. Perché dei giudici anonimi, scelti segretamente dalla direzione di una rivista, dovrebbero garantire una valutazione accurata e imparziale dei ...
Maria Chiara Pievatolo
doaj
Recent Issues in Medical Journal Publishing and Editing Policies: Adoption of Artificial Intelligence, Preprints, Open Peer Review, Model Text Recycling Policies, Best Practice in Scholarly Publishing 4th Version, and Country Names in Titles. [PDF]
Huh S.
europepmc +1 more source
Soft peer review: social software and distributed scientific evaluation [PDF]
The debate on the prospects of peer-review in the Internet age and the increasing criticism leveled against the dominant role of impact factor indicators are calling for new measurable criteria to assess scientific quality. Usage-based metrics offer a
Taraborelli, D.
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
What does peer review mean in OER? Are the student reviews of an OER in the classroom more important than peer reviewing by other faculty? Come watch a recorded webinar from the Open Textbook Network and discuss peer review & OER during Open Education ...
Rebus Community, Open Textbook Network
core
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source

