Results 121 to 130 of about 2,192,791 (336)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Open Peer Review: Collective Intelligence as a Framework for Theorizing Approaches to Peer Review in the Humanities

NANO, 2013
This article takes a moderate approach, balancing suggestions for when open peer review can benefit scholarship in the humanities, while offering important concerns authors and editors must consider before deciding to implement the process.
Jenna Pack Sheffield
doaj  

Making the most of peer review

eLife, 2015
Journals should publish referee reports and respond to well-founded concerns about papers after publication.
Nikolai Slavov
doaj   +1 more source

Peer Review Week 2021: Preprints Meet Open Peer Review

, 2021
<em> <strong> Embracing identity in Peer Review </strong> </em> The COVID-19 pandemic has brought into stark focus is the importance of both a speedy dissemination of research (something our participation in the C19 Rapid Review Consortium has tried to tackle), and the need to be able to trust the validity of this information.
openaire   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Open peer review commentary on building clinically relevant outcomes across the Alzheimer's disease spectrum. [PDF]

Alzheimers Dement (N Y), 2021
Rockwood K.
europepmc   +1 more source

Introduction of Organic Eprints [PDF]

, 2011
Organic Eprints is an open, on-line archive for research in organic food and farming with more than 10,000 publications - and growing rapidly. All use of the archive is free of charge. There are 15,000 registered users of Organic Eprints, and the archive
Rasmussen, Ilse A.
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Open science publishing practices can break commercial publishers’ dominant position in the dissemination of scientific results

Dutch Journal of Applied Linguistics
In this response to Diamond is a scientist's best friend, Pascal Braak discusses open science practices from a bibliographic perspective and among other things, sketches how a fully open and transparent knowledge generation process may break the power ...
Pascal Braak
doaj   +1 more source