Results 141 to 150 of about 668,202 (287)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Possibilities of Open Peer Review
, 2021 Students, undergraduate and graduate alike, must engage with the peer-reviewed literature. Yet, peer-review processes are often opaque and unique to the communities in which they occur.
Ford, Emily
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Soft peer review: social software and distributed scientific evaluation
, 2008 The debate on the prospects of peer-review in the Internet age and the increasing criticism leveled against the dominant role of impact factor indicators are calling for new measurable criteria to assess scientific quality. Usage-based metrics offer a
Taraborelli, D.
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Is it worth to establishing institutional repositories? The strategies for Open Access to Spanish peer-reviewed articles. [PDF]
, 2010 We examine open access to the Spanish scientific literature through investigation of a sample of peer reviewed articles in seven subject categories.
Rodríguez, Nerea, Amat, Carlos B.
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Peer Review Process: Past, Present, and Future
British Journal of Biomedical ScienceThe peer review process is a fundamental aspect of modern scientific paper publishing, underpinning essential quality control. First conceptualised in the 1700s, it is an iterative process that aims to elevate scientific literature to the highest ...
John A. Drozdz, Michael R. Ladomery
doaj +1 more source
Open Science, Closed Peer Review?
Open science initiatives have gained traction in recent years. However, open peer-review practices, i.e., reforms that (i) modify the identifiability of stakeholders and (ii) establish channels for the open communication of information between stakeholders, have seen very little adoption in economics.
Daniel Evans +4 more
openaire +2 more sources