Results 151 to 160 of about 668,202 (287)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

An Open Peer Review Primer

open access: yes, 2017
<p>Presentation given for Webinar „Open Peer Review“ for Wikimedia Germany's Open Science Fellows' Programme on 29.
Ross-Hellauer, Tony (5254534)   +1 more
core   +1 more source

Open Ethos Publishing at Code4Lib Journal and In the Library with the Lead Pipe

open access: yesIn the Library with the Lead Pipe, 2012
In Brief: The library world is deeply entrenched in the open ethos, yet there are few examples of library publications that engage in open editorial and peer review processes.
Emily Ford
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Strategies of Peer‐Assisted Learning and Their Effectiveness in Nursing Education: A Systematic Review

open access: yes, 2016
The purpose of this study is to identify factors associated with effective peer-assisted learning (PAL) for nursing students. This review examined studies on PAL in nursing education.
연세대학교 의과대학
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

A Brief Introduction on Peer Review: New Possibilities

open access: yes, 2013
From the classroom, to the lab, to the studio, to industry, and to the academy, evaluating work is part of everyday life. Whether we call it critiquing, refereeing, or peer reviewing, the goals are the same: to make the object under review better, to ...
Sean Scanlan
core  

Hot Takes on Open Peer Review

open access: yes, 2022
Open peer review, for the purposes of this panel discussion, is defined as authors and reviewers knowing the identities of one another during the peer review phase of scholarly publishing. This panel will feature three individuals with varying viewpoints
Baribeau, Hilary   +3 more
core  

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