Results 91 to 100 of about 1,409,999 (372)

Replication enhancer elements within the open reading frame of tick-borne encephalitis virus and their evolution within the Flavivirus genus [PDF]

open access: yes, 2011
We provide experimental evidence of a replication enhancer element (REE) within the capsid gene of tick-borne encephalitis virus (TBEV, genus Flavivirus).
Buckley, A.   +5 more
core   +3 more sources

Small open reading frames: Not so small anymore [PDF]

open access: yesGenome Research, 2006
Today, nearly 10 years after the publication of the complete sequence of the Saccharomyces cerevisiae genome, the total number of genes in this organism is largely considered resolved and currently stands at 5782 (http://www.yeastgenome.org/cache/ genomeSnapshot.html).
Brenda J. Andrews, Richelle Sopko
openaire   +3 more sources

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

open access: yesFEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter   +8 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Identification of core therapeutic targets for Monkeypox virus and repurposing potential of drugs: A WEB prediction approach.

open access: yesPLoS ONE
A new round of monkeypox virus has emerged in the United Kingdom since July 2022 and rapidly swept the world. Currently, despite numerous research groups are studying this virus and seeking effective treatments, the information on the open reading frame,
Huaichuan Duan   +10 more
doaj   +1 more source

Deduced Primary Structure of the β Subunit of Brain Type II Ca2+/calmodulin-dependent Protein Kinase Determined by Molecular Cloning [PDF]

open access: yes, 1987
cDNA clones coding for the β subunit of rat brain type II Ca2+/calmodulin-dependent protein kinase were isolated and sequenced. The clones, including one containing the entire coding region, hybridize at high stringency to a single band of poly(A)+ RNA ...
Bennett, Mark K., Kennedy, Mary B.
core  

Flatworms have lost the right open reading frame kinase 3 gene during evolution [PDF]

open access: yes, 2015
All multicellular organisms studied to date have three right open reading frame kinase genes (designated riok-1, riok-2 and riok-3). Current evidence indicates that riok-1 and riok-2 have essential roles in ribosome biosynthesis, and that the riok-3 gene
Amani, Parisa   +9 more
core   +1 more source

Translation of upstream open reading frames in a model of neuronal differentiation [PDF]

open access: yesBMC Genomics, 2018
AbstractUpstream open reading frames (uORFs) initiate translation within mRNA 5’ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside. Ribosome profiling (RP) studies suggest that translating ribosomes are pervasive within 5’ leaders across model systems.
Rodriguez, C.M.   +3 more
openaire   +6 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Designing a New Multiepitope-based Vaccine Against COVID-19

open access: yesResearch in Molecular Medicine, 2021
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has currently caused a significant pandemic among worldwide populations. The high transmission and mortality rates of the disease necessitate studies for rapid designing and ...
Afshin Samimi Nemati   +4 more
doaj  

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