Results 71 to 80 of about 276,768 (304)
Designing a New Multiepitope-based Vaccine Against COVID-19
Research in Molecular Medicine, 2021 Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has currently caused a significant pandemic among worldwide populations. The high transmission and mortality rates of the disease necessitate studies for rapid designing and ...
Afshin Samimi Nemati +4 more
doaj
An Upstream Open Reading Frame Represses Translation of Chicken PPARγ Transcript Variant 1
Frontiers in Genetics, 2020 Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipogenesis. The PPARγ gene produces various transcripts with different 5′-untranslated regions (5′ UTRs) because of alternative promoter usage and splicing.
Yankai Chu +20 more
doaj +1 more source
Translational control of murine adiponectin expression by an upstream open reading frame element
RNA Biology, 2023 Adiponectin, an adipocyte-specific secretory protein encoded by the ADIPOQ gene has a causal role in insulin resistance. Anti-diabetic drugs increase plasma adiponectin by a poorly understood, post-transcriptional mechanism enhancing insulin sensitivity.
Kommireddy Vasu +6 more
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
An upstream open reading frame modulates ebola virus polymerase translation and virus replication. [PDF]
PLoS Pathogens, 2013 Ebolaviruses, highly lethal zoonotic pathogens, possess longer genomes than most other non-segmented negative-strand RNA viruses due in part to long 5' and 3' untranslated regions (UTRs) present in the seven viral transcriptional units. To date, specific
Reed S Shabman +7 more
doaj +1 more source
Putative identified heat shock protein genes with complete open reading frame.
, 2016 Putative identified heat shock protein genes with complete open reading frame.
Hao Xia (3093831) +7 more
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Biologia Plantarum, 2010 In the conversion of oleic acid to linoleic acid, δ12-fatty acid desaturase (δ12-FAD) is involved. Based on the conserved oligo amino acid residues of the FAD2 genes from other plants, a new full-length cDNA (DiFAD2) encoding a δ12-FAD was cloned from ...
N. Lei +8 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Mitochondrial peptide BRAWNIN is essential for vertebrate respiratory complex III assembly
Nature Communications, 2020 Small open reading frame-encoded peptides (SEPs), shorter than 100 amino acids, are involved in many cell biological processes. Here the authors identify 16 nuclear-encoded mitochondrial SEPs, including BRAWNIN, an essential regulator of respiratory ...
Shan Zhang +26 more
doaj +1 more source