Results 91 to 100 of about 276,768 (304)
Open Reading Frame 4 protein as potential drug target for HEV: Structural evaluation through computational approaches [PDF]
Hepatitis E virus (HEV) is the main cause of acute hepatitis worldwide. The viral infection caused by G1 HEV in pregnant women has become a major health concern in the past few years. The mechanism underlying the pathogenesis of viral infection in HEV G1
Shama Parveen, Zoya Shafat
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart +5 more
wiley +1 more source
A Potential Negative-Strand Open Reading Frame in Zika Virus
, 2020 Zika virus (ZIKV) is a recently emergent flavivirus transmitted by mosquitoes that is medically important due to neurological complications in the fetuses of infected mothers in the form of microcephaly, and less frequently in adults seen with cases of ...
Currie, Caroline
core +1 more source
Differential expression of chromosome 11 open reading frame 80 in cancers of the breast.
, 2022 Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients ...
Shahan Mamoor
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Advanced Engineering Materials, Volume 27, Issue 6, March 2025.The stability criteria affecting the formation of high‐entropy alloys, particularly focusing in supersaturated solid solutions produced by mechanical alloying, are analyzed. Criteria based on Hume–Rothery rules are distinguished from those derived from thermodynamic relations. The formers are generally applicable to mechanically alloyed samples.
Javier S. Blázquez +5 more
wiley +1 more source
VirusesViruses frequently contain overlapping genes, which encode functionally unrelated proteins from the same DNA or RNA region but in different reading frames. Yet, overlapping genes are often overlooked during genome annotation, in particular in DNA viruses.
David G. Karlin
doaj +1 more source
Virology Journal, 2010 Background Human pathogenic coronavirus NL63 (hCoV-NL63) is a group 1 (alpha) coronavirus commonly associated with respiratory tract infections. In addition to known non-structural and structural proteins all coronaviruses have one or more accessory ...
Suliman Tasnim +10 more
doaj +1 more source
2A - the "go-to" technology for transgene co-expression
, 2015 In order to co-express multiple genes for biotechnological and biomedical applications, several approaches have been used with varying degrees of success.
Minskaia, Ekaterina, Luke, Garry Alec
core +1 more source