Open reading frame - Open Access .click

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Inferring genes from open reading frames

Computers & Chemistry, 1994
One expects that in DNA without protein coding function, stop codons (which constitute three of the 64 possible codons) should occur frequently in all reading frames, and that a long open reading frame (ORF) can be interpreted as a sign for the existence of a gene.
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Coupling of Open Reading Frames by Translational Bypassing

Annual Review of Biochemistry, 2000
▪ Abstract Translational bypassing joins the information found within two disparate open reading frames into a single polypeptide chain. The underlying mechanism centers on the decoding properties of peptidyl-transfer RNA (tRNA) and involves three stages: take-off, scanning, and landing.
A J, Herr, J F, Atkins, R F, Gesteland
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Bioprospecting Open Reading Frames for Peptide Effectors

2013
Recent successes in the development of small-molecule antagonists of protein-protein interactions designed based on co-crystal structures of peptides bound to their biological targets confirm that short peptides derived from interacting proteins can be high-value ligands for pharmacologic validation of targets and for identification of druggable sites.
Ling, Xiong, Charles, Scott
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Open reading frames and translational control