Results 101 to 110 of about 627,878 (334)

Gene expression regulation by upstream open reading frames in rare diseases [PDF]

, 2017
Upstream open reading frames (uORFs) constitute a class of cis-acting elements that regulate translation initiation. Mutations or polymorphisms that alter, create or disrupt a uORF have been widely associated with several human disorders, including ...
Fernandes, Rafael, Romão, Luísa, Silva, Joana   +2 more
core  

Phage ϕC2 mediates transduction of Tn6215, encoding erythromycin resistance, between Clostridium difficile strains [PDF]

, 2013
UNLABELLED: In this work, we show that Clostridium difficile phage ϕC2 transduces erm(B), which confers erythromycin resistance, from a donor to a recipient strain at a frequency of 10(-6) per PFU.
Chang, Barbara J, Emmett, Warren, Goh, Shan, Hussain, Haitham, Mullany, Peter, Riley, Thomas V   +5 more
core   +3 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

In silico protein prediction of the 16S ribosomal RNA gene from novel rhizobacterium Bacillus cereus UPMLH24 [PDF]

, 2014
In this study, computational methods were used to predict information hidden in the small subunit 16S rRNA gene from newly isolated plant growth-promoting rhizobacteria B. cereus strain UPMLH24.
Abdul Aziz, Zakry Fitri, Abdul Rahim, Khairuddin, Ahmed, Osumanu Haruna, Mohd Saud, Halimi   +3 more
core  

Bad Phages in Good Bacteria: Role of the Mysterious orf63 of λ and Shiga Toxin-Converting 824B Bacteriophages [PDF]

, 2017
Lambdoid bacteriophages form a group of viruses that shares a common schema of genome organization and lifecycle. Some of them can play crucial roles in creating the pathogenic profiles of Escherichia coli strains. For example, Shiga toxin-producing E.
Bloch, Sylwia, Donaldson, Logan W., Dydecka, Aleksandra, Gąsior, Tomasz, Necel, Agnieszka, Nejman-Faleńczyk, Bożena, Perez, Shaili, Rizvi, Ali, Topka, Gracja, Węgrzyn, Alicja, Węgrzyn, Grzegorz   +10 more
core   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

Sequence analysis and genomic organization of Aphid lethal paralysis virus: a new member of the family Dicistroviridae [PDF]

, 2002
The complete nucleotide sequence of the genomic RNA of an aphid-infecting virus, Aphid lethal paralysis virus (ALPV), has been determined. The genome is 9812 nt in length and contains two long open reading frames (ORFs), which are separated by an ...
Clerivet, A., Dullemans, A.M., Heuvel, J.F.J.M., van den, Munster, M., van, Verbeek, M., Wilk, F., van der   +5 more
core   +2 more sources

Small open reading frames and cellular stress responses

Molecular Omics, 2019
Increasing evidence suggests that some small open reading frame-encoded polypeptides (SEPs) function in prokaryotic and eukaryotic cellular stress responses.
Alexandra Khitun, Travis J. Ness, Sarah A. Slavoff   +2 more
openaire   +3 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source