Results 21 to 30 of about 780,027 (226)

Upstream open reading frames buffer translational variability during Drosophila evolution and development [PDF]

eLife
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown.
Yuanqiang Sun, Yuange Duan, Peixiang Gao, Chenlu Liu, Kaichun Jin, Shengqian Dou, Wenxiong Tang, Hong Zhang, Jian Lu   +8 more
doaj   +2 more sources

Translation of upstream open reading frames in a model of neuronal differentiation

BMC Genomics, 2019
Background Upstream open reading frames (uORFs) initiate translation within mRNA 5′ leaders, and have the potential to alter main coding sequence (CDS) translation on transcripts in which they reside.
Caitlin M. Rodriguez, Sang Y. Chun, Ryan E. Mills, Peter K. Todd   +3 more
doaj   +2 more sources

Short internal open reading frames repress the translation of N-terminally truncated proteoforms [PDF]

EMBO Reports
Internal translation initiation sites, as revealed by ribosome profiling experiments can potentially drive the translation of many N-terminally truncated proteoforms.
Raphael Fettig, Zita Gonda, Niklas Walter, Paul Sallmann, Christiane Thanisch, Markus Winter, Susanne Bauer, Lei Zhang, Greta Linden, Margarethe Litfin, Marina Khamanaeva, Sarah Storm, Christina Münzing, Christelle Etard, Olivier Armant, Olalla Vázquez, Olivier Kassel   +16 more
doaj   +2 more sources

Open Reading Frame Phylogenetic Analysis on the Cloud [PDF]

International Journal of Genomics, 2013
Phylogenetic analysis has become essential in researching the evolutionary relationships between viruses. These relationships are depicted on phylogenetic trees, in which viruses are grouped based on sequence similarity.
Che-Lun Hung, Chun-Yuan Lin
doaj   +3 more sources

Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames

Molecules and Cells, 2023
Summary All species continuously evolve short open reading frames (sORFs) that can be templated for protein synthesis and may provide raw materials for evolutionary adaptation.
Clara Sandmann, J. Schulz, Jorge Ruiz-Orera, Marieluise Kirchner, M. Ziehm, E. Adami, Maike Marczenke, Annabel Christ, Nina Liebe, J. Greiner, Aaron Schoenenberger, M. Muecke, Ning Liang, R. Moritz, Zhi Sun, E. Deutsch, M. Gotthardt, Jonathan M. Mudge, John R. Prensner, T. Willnow, Philipp Mertins, Sebastiaan van Heesch, N. Hubner   +22 more
semanticscholar   +1 more source

Identification of proteoforms of short open reading frame-encoded peptides in Blautia producta under different cultivation conditions

Microbiology Spectrum, 2023
Short open reading frames (sORF) have the potential to encode small proteins, sORF-encoded peptides (SEP), which are less than or equal to 100 amino acids in length.
Jerome Genth, Kathrin Schäfer, Liam Cassidy, Simon Graspeuntner, Jan Rupp, Andreas Tholey   +5 more
doaj   +1 more source

Non-conventional peptides in plants: From gene regulation to crop improvement

Crop Journal, 2023
Conventional peptides (CPs) and non-conventional peptides (NCPs) are generated from small open reading frames, but most CPs are derived from large precursors. NCPs, which are derived from sequences other than conventional open reading frames or annotated
Huan Chen, Jingjuan Yu, Wen-Xue Li
doaj   +1 more source

The dark proteome: translation from noncanonical open reading frames.

Trends in Cell Biology, 2021
Omics-based technologies have revolutionized our understanding of the coding potential of the genome. In particular, these studies revealed widespread unannotated open reading frames (ORFs) throughout genomes and that these regions have the potential to ...
Bradley W. Wright, Zixin Yi, J. Weissman, Jin Chen   +3 more
semanticscholar   +1 more source

Short open reading frames (sORFs) and microproteins: an update on their identification and validation measures

Journal of Biomedical Sciences, 2022
A short open reading frame (sORFs) constitutes ≤ 300 bases, encoding a microprotein or sORF-encoded protein (SEP) which comprises ≤ 100 amino acids. Traditionally dismissed by genome annotation pipelines as meaningless noise, sORFs were found to possess ...
Alyssa Zi-Xin Leong, Pey Yee Lee, M. Mohtar, S. Syafruddin, Y. Pung, T. Low   +5 more
semanticscholar   +1 more source

Coupled protein synthesis and ribosome-guided piRNA processing on mRNAs

Nature Communications, 2021
Ribosome can mediate piRNA biogenesis from long non-coding RNAs following translation of the short open reading frames. Here the authors show that 80S ribosome also guides piRNA production from 3’ UTR of protein-coding genes after translation of long ...
Yu H. Sun, Ruoqiao Huiyi Wang, Khai Du, Jiang Zhu, Jihong Zheng, Li Huitong Xie, Amanda A. Pereira, Chao Zhang, Emiliano P. Ricci, Xin Zhiguo Li   +9 more
doaj   +1 more source