Results 21 to 30 of about 159,413 (329)

Translational regulation of PKD1 by evolutionarily conserved upstream open reading frames [PDF]

RNA Biology
Mutations in PKD1 coding sequence and abnormal PKD1 expression levels contribute to the development of autosomal-dominant polycystic kidney disease, the most common genetic disorder. Regulation of PKD1 expression by factors located in the promoter and 3´
Lei Chen, Xia Gao, Xiangshen Liu, Ye Zhu, Dong Wang   +4 more
doaj   +2 more sources

Pervasiveness of Microprotein Function Amongst Drosophila Small Open Reading Frames (SMORFS) [PDF]

Cells
Small Open Reading Frames (smORFs) of less than 100 codons remain mostly uncharacterised. About a thousand smORFs per genome encode peptides and microproteins about 70–80 aa long, often containing recognisable protein structures and markers of ...
Ana Isabel Platero, Jose Ignacio Pueyo, Sarah Anne Bishop, Emile Gerard Magny, Juan Pablo Couso   +4 more
doaj   +2 more sources

Upstream open reading frames may contain hundreds of novel human exons. [PDF]

PLoS Computational Biology
Several recent studies have presented evidence that the human gene catalogue should be expanded to include thousands of short open reading frames (ORFs) appearing upstream or downstream of existing protein-coding genes, each of which might create an ...
Hyun Joo Ji, Steven L Salzberg
doaj   +2 more sources

AlterORF: a database of alternate open reading frames [PDF]

Nucleic Acids Research, 2008
AlterORF is a searchable database that contains information regarding alternate open reading frames (ORFs) for over 1.5 million genes in 481 prokaryotic genomes.
Holmes, David S., Veloso, Felipe A., Pedroso, Inti, Rivera, Gustavo, Ossandon, Francisco, Chacon, Max, Lazo, Felipe   +6 more
core   +11 more sources

ORFer – retrieval of protein sequences and open reading frames from GenBank and storage into relational databases or text files

BMC Bioinformatics, 2002
Background Functional genomics involves the parallel experimentation with large sets of proteins. This requires management of large sets of open reading frames as a prerequisite of the cloning and recombinant expression of these proteins.
Sievert Volker, Hoffmann Steve, Büssow Konrad   +2 more
doaj   +2 more sources

Mutational constraint analysis workflow for overlapping short open reading frames and genomic neighbors [PDF]

BMC Genomics
Understanding the dark genome is a priority task following the complete sequencing of the human genome. Short open reading frames (sORFs) are a group of largely unexplored elements of the dark genome with the potential for being translated into ...
Martin Danner, Matthias Begemann, Florian Kraft, Miriam Elbracht, Ingo Kurth, Jeremias Krause   +5 more
doaj   +2 more sources

Maize Anther Development Involves Translated Open Reading Frames From 3′ Untranslated Regions [PDF]

Advanced Science
Few studies have explored the functions of peptides encoded by open reading frames (ORFs) in annotated noncoding regions, particularly the 3′ untranslated regions (3′ UTRs).
Chunyu Wang, Yuechao Wu, Shunxi Wang, Han Liu, Siqi Jiang, Yingjia Han, Liuji Wu, Tao Zhang, Mei Zhang   +8 more
doaj   +2 more sources

Upstream open reading frames buffer translational variability during Drosophila evolution and development [PDF]

eLife
Protein abundance tends to be more evolutionarily conserved than mRNA levels both within and between species, yet the mechanisms underlying this phenomenon remain largely unknown.
Yuanqiang Sun, Yuange Duan, Peixiang Gao, Chenlu Liu, Kaichun Jin, Shengqian Dou, Wenxiong Tang, Hong Zhang, Jian Lu   +8 more
doaj   +2 more sources

Statistical properties of open reading frames in complete genome sequences

Computers & Chemistry, 1999
Some statistical properties of open reading frames in all currently available complete genome sequences are analyzed (seventeen prokatyotic genomes, and 16 chromosome sequences from the yeast genome).
Wentian Li
exaly   +1 more source

An expanded reference catalog of translated open reading frames for biomedical research. [PDF]

Nucleic Acids Res
Chothani S, Ruiz-Orera J, Tierney JAS, Swirski MI, Tjeldnes H, Kok LW, Clauwaert J, Deutsch EW, Alba MM, Aspden JL, Baranov PV, Bazzini AA, Bruford EA, Brunet MA, Cardon T, Carvunis AR, Casola C, Choudhary JS, Dean K, Faridi P, Fierro-Monti I, Fournier I, Frankish A, Gerstein M, Hubner N, Jiang Y, Kellis M, Martinez TF, Menschaert G, Ni P, Orchard S, Roucou X, Rozowsky J, Salzet M, Siragusa M, Slavoff S, Ternette N, Vizcaino JA, Wacholder A, Wu W, Xie Z, Yang YT, Moritz RL, Valen E, Mudge J, van Heesch S, Prensner JR, Rackham OJL.   +47 more
europepmc   +2 more sources