Results 91 to 100 of about 16,981,451 (257)

Primary Petit's Triangle Hernia With Bowel Strangulation: Management in a Resource‐Limited Setting

Clinical Case Reports
Lumbar hernias are rare surgical entities that may present asymptomatically or with complications such as obstruction and strangulation. We report a case of a 45‐year‐old woman who presented to the emergency department with a painful, irreducible ...
Biruk Umer Mohammed, Henok Bahru Wodajeneh, Ashenafi Tesfaye Bedada, Frewoyni Gedey Gebregziabher, Dereje Nigatu Elala   +4 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Statin therapy is associated with improved survival after endovascular and open aneurysm repair

, 2014
Background The relationship between numerous risk factors and perioperative mortality after cardiovascular surgery has been studied extensively. While improved perioperative survival and fewer cardiovascular events have been related to statin therapy ...
Heymans, M.W., Grobbee, D.E., Prinssen, M., de Bruin, J.L., Baas, A.F., Blankensteijn, J.D., Buimer, M.G.   +6 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Comparación entre la cirugía abierta y el método mínimamente invasivo para roturas agudas del tendón de Aquiles. [Comparison between open surgery and the minimally invasive method for acute Achilles tendon ruptures.]

Revista de la Asociación Argentina de Ortopedia y Traumatología, 2016
Introducción. La reparación quirúrgica puede realizarse mediante cirugía abierta o por técnicas mínimamente invasivas. La técnica percutánea combina las ventajas del tratamiento quirúrgico abierto con el tratamiento ortopédico.
Ignacio Ricardo Arzac Ulla, Adrian De Silvestri, Gustavo Fiorentini   +2 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Repair in the circular economy

In this white paper, experts from science and practice share their knowledge of product repair. Repair is an important pillar of the circular economy as it is more efficient to repair a product than to completely dismantle or destroy it and recycle the ...

core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A novel method of articular cartilage repair. [PDF]

, 2007
Articular cartilage repair of post-traumatic articular cartilage defects and well-defined articular cartilage pathology is challenging in clinical practice and has been the focus of investigations for many years.
Reissis, N., Reissis, Nikolaos
core