Results 81 to 90 of about 16,981,451 (257)

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Long-term outcome of open or endovascular repair of abdominal aortic aneurysm. [PDF]

, 2010
Contains fulltext : 87282.pdf (Publisher’s version ) (Open Access)BACKGROUND: For patients with large abdominal aortic aneurysms, randomized trials have shown an initial overall survival benefit for elective endovascular repair over ...
Buth, J. (Jaap), Cuypers, P.W., Grobbee, D.E., Verhoeven, E.L.G., Blankensteijn, Jan D., Blankensteijn, J.D., Verhoeven, E.L.G. (Eric), Blankensteijn, J.D. (Jan), J.L. De Bruin, J. Buth, Balm, Ron, van Sambeek, M.R.H.M., Verhoeven, Eric L. G., Bruin, J.L. De, Cuypers, P.M.W. (Philippe), van Engelshoven, Josephus, Balm, R. (Ron), Balm, R., Van Sambeek, Marc R.H.M., Prinssen, M. (Monique), Buth, Jaap, Bruin, J.L. (Jorg) de, De Bruin, J.L., Cuypers, Philippe W.M., Baas, Annette F., Verhoeven, E.L., Cuypers, Philippe W. M., Baas, A.F., De Bruin, Jorg L., Sambeek, M.R. van, Sambeek, M.R.H.M. (Marc) van, Cuypers, P.W.M., Grobbee, D.E. (Diederick), Verhoeven, Eric L.G., Baas, A.F. (Annette), Prinssen, M., A.F. Baas, Buth, J., Prinssen, Monique, Grobbee, Diederick E., van Sambeek, Marc R. H. M.   +40 more
core   +1 more source

Boat Repair Austin TX

, 2021
What is boat repair? Boat repair is the most fundamental piece of cruising for mariners, or for everybody that claims a boat. Boat fixes are generally done continually. Indeed, you have perused it right. Boat repair ought to be done consistently.
Boat Repair Austin
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Laparoscopic vs open incisional hernia repair a randomized clinical trial

, 2013
Importance: Incisional hernia is the most frequent surgical complication after laparotomy. Up to 30% of all patients undergoing laparotomy develop an incisional hernia.
Eker, H.H. (Hasan), Hansson, B.M.E., Hop, W.C., Pierik, R.E.G.J.M. (Robert), Eker, Hasan, Eker, H.H., Janssen, IMC, Jeekel, J (Hans), Pierik, R.E.G.J., Buunen, Mark, Lange, J.F., Bonjer, HJ (Jaap), Janssen, I.M.C., Lange, Johan, Hop, Wim C.J., Hansson, BME, Hansson, B.M., Bonjer, H.J., Pierik, REGJM, Buunen, M. (Mark), Lange, J.F. (Johan), Hop, Janssen, I.M.C. (Ignace), Bonjer, H.J. (Jaap), Jeekel, J., Hop, W.C.J. (Wim), Jeekel, J. (Hans), Buunen, M   +27 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source