Results 61 to 70 of about 807,503 (348)
Theoretical and Applied Mechanics LettersThis study addresses the significant disparity in aerodynamic uplift forces experienced by single-strip high-speed pantographs under different operating directions.
Yafeng Zou +4 more
doaj +1 more source
E3S Web of Conferences, 2018 The paper unveils relevance of applying the methodology of multi-level modeling of thermal-hydraulic conditions of heat supply systems (HSS) and the software which are realized in the informationcomputing system “ANGARA-TS”, which make possible ...
Shalaginiva Zoya I. +1 more
doaj +1 more source
Asymmetric targeting of corporate cash holdings and financial constraints in Pakistani firms [PDF]
Journal of Asian Business and Economic Studies, 2019 Purpose – The purpose of this paper is to investigate the asymmetric adjustment of cash holdings in Pakistani firms for above and below target firms. Design/methodology/approach – The study employs generalized method of moments (GMM) to investigate the ...
Ghulam Ayehsa Siddiqua +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Basu measure as an indicator of conditional conservatism: Evidence from U.K. earnings components [PDF]
, 2012 Following the work of Basu in 1997, the excess of the sensitivity of accounting earnings to negative share return over its sensitivity to positive share return (the Basu coefficient) has been interpreted as an indicator of conditional accounting ...
Hsu, A, O'Hanlon, J F, Peasnell, K V
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Development of an Adjustable Gripper for Robotic Picking and Placing Operation [PDF]
International Journal on Smart Sensing and Intelligent Systems, 2012 Abstract Adjustable gripper for robotic system that is capable in identifying shape and size of an object is needed in many applications especially for picking and placing operation. This is due to some of the grippers’ design are limited only to one specific shape or size that make picking and placing operation difficult.
Che Soh, A. +3 more
openaire +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source