Results 111 to 120 of about 300,033 (304)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Multi-disciplinary robust design of variable speed wind turbines [PDF]
, 2011 This paper addresses the preliminary robust multi-disciplinary design of small wind turbines. The turbine to be designed is assumed to be connected to the grid by means of power electronic converters.
Vasile, Massimiliano +4 more
core
Power Limitation Control for a PMSG-Based Marine Current Turbine at High Tidal Speed and Strong Sea State [PDF]
, 2013 This paper deals with the control strategies for a fixed-pitch marine current turbine (MCT) when the marine current speed exceeds the rated value corresponding to the rated power of generator and converter.
SCUILLER, Franck +10 more
core +1 more source
Sight distance analyses in road design process: Serbian practice
Transport, 2016 New Serbian policies on road design introduce the concept of operating speeds. Decades ago, national policies were based on the constant design speed concept.
Dejan Gavran +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Operating-Speed Model for Low-Speed Urban Tangent Streets Based on In-Vehicle Global Positioning System Data [PDF]
, 2006 Low-speed urban streets are designed to provide both access and mobility and to accommodate multiple road users, such as bicyclists and pedestrians. However, speeds on these facilities often exceed the intended operating speeds, as well as their design ...
Jun Wang +3 more
core +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Analysis of inconsistencies related to design speed, operating speed, and speed limits. [PDF]
KYSPR-286-04The objective of this research was to examine the relationship among design speeds, operating speeds and speed limits and address safety and operational concerns regarding the presence of disparities among these speed metrics.
Stamatiadis, Nikiforos +2 more
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source