Results 71 to 80 of about 3,152,811 (245)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Predicting Operating Speeds of Passenger Cars on Single-Carriageway Road Tangents
InfrastructuresThis research addresses the challenge of predicting operating vehicles’ speeds (V85) on single-carriageway road tangents. While most previous models rely on preceding segment speeds or focus on curves, this research develops an independent prediction ...
Juraj Leonard Vertlberg +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Operating system support for high-speed networking.
, 1994 The advent of high-speed networks may soon increase the network bandwidth available to workstation class computers by two orders of magnitude. Combined with the dramatic increase in microprocessor speed, these technological advances make possible new ...
Druschel, Peter
core +5 more sources
Predicting Operating Speeds of Passenger Cars on Dual–Carriageway Road Tangents
Promet (Zagreb)This research develops multiple linear regression models for predicting operating speeds (V85) of passenger cars on dual–carriageway road tangents in Croatia, separately for the right (driving) and left (overtaking) lanes.
Juraj Leonard VERTLBERG +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Speed Harmonization--Design Speed vs. Operating Speed
, 2016 When the actual operating speed on the roads exceeds the design speed, which is common on rural highways, the roadway design may become problematic from a safety point of view.
Jiang, Zhoutong +2 more
core +1 more source
Zhongwai GongluTo investigate the influence of horizontal curve radius on vehicle fuel consumption and pollutant emissions on two-lane highways, this study developed a model based on running speed theory, vehicle driving dynamics, and a fuel consumption and emission ...
TU Shengwen, LEI Meimei, GUO Wenyu
doaj +1 more source