Results 81 to 90 of about 3,152,811 (245)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
IATSS Research, 2013 A speed limit of 30 kilometres per hour (km/h) has been widely introduced for urban residential streets to ensure traffic safety and allow these streets to fulfil other intended functions. However, excessive speeds on these roads are very common, causing
Do Duy Dinh, Hisashi Kubota
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Social Shaping of Technological Trajectories of Shinkansen
Annals of Business Administrative Science, 2016 The Tokaido Shinkansen began operating in 1964 and ran at globally unprecedented speeds of more than 200 kmph. Comparison with the operating speed of aircraft necessitated further improvement of the operating speed of Shinkansen.
Hiroki KIKUCHI
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Operating Speed Model for Low-Speed Rural Two-Lane Highways
, 2011 Operating speed, with its deviations along tangent and curve segments of highways, is one of the most common measures to evaluate the consistency of rural two-lane highways.
Hui Wang +2 more
core +1 more source
Car driver speed choice in Scotland [PDF]
, 2007 Drivers who commit driving violations, such as speeding, crash more. Driving violations reduce safety margins amplifying the impact of driver errors. Speed is placed in the context of car use and its attractions.
Stradling, Stephen G
core +1 more source
Sight distance analyses in road design process: Serbian practice
Transport, 2016 New Serbian policies on road design introduce the concept of operating speeds. Decades ago, national policies were based on the constant design speed concept.
Dejan Gavran +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Operating leases and the assessment of lease-debt substitutability [PDF]
, 2000 Operating leases are estimated in the current paper to be approximately thirteen times larger than finance leases, on average. In recognition of this, the paper investigates the degree of substitutability between leasing and non-lease debt using a ...
Goodacre, Alan +6 more
core +1 more source