Results 81 to 90 of about 300,033 (304)

Simulation of bulk flow and high speed operations [PDF]

Proceedings of the 29th conference on Winter simulation - WSC '97, 1997
Simulation modeling can be highly effective for solving problems found in the food, beverage, consumer products, and pharmaceutical industries. The flow of material or fluid in these industries is often described as bulk flow, continuous, semi-continuous, or high-speed.
Andrew J. Siprelle, Richard A. Phelps
openaire   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Determining Factors Influencing Operating Speeds on Road Tangents

Applied Sciences
Road traffic accidents remain a critical global issue with approximately 1.19 million fatalities each year, on which excessive and inappropriate speeds contribute significantly.
Juraj Leonard Vertlberg, Marijan Jakovljević, Borna Abramović, Marko Ševrović   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Simulation Analysis of Factors Influencing Vehicle Passing Performance through Large-slope Metro Turnouts

Chengshi guidao jiaotong yanjiu
Objective In the actual metro construction, it is often necessary to lay turnouts on large-slope sections due to planning and construction constraints, land conservation or topographical limitations.
CHEN Qiaosong, RUAN Ying, WANG Mingmin, MA Qiantao, HOU Mingyang, CHEN Rong, XU Jingmang   +6 more
doaj   +1 more source

Pressure, Flow Rate and Operating Speed Characteristics of a Continuous Flow Left Ventricular Assist Device During Varying Speed Support

IEEE Access, 2020
Hydraulic performance of Continuous Flow Left Ventricular Assist Devices depends on their pressure head and flow rate relations. Hydraulic characteristics of these devices are expressed by pressure head and flow rate loops in a pulsatile environment as ...
Selim Bozkurt
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source