Results 151 to 160 of about 63,196 (314)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Improving the connection of EIP-Agri Operational Groups and Horizon Europe

Hanna Tamsalu, von Münchhausen, Mark Redman, Jordi Pietx   +3 more
openalex   +1 more source

Operationalizing the Mind–Body Connection: Interoception via the Autonomic Nervous System [PDF]

Brittany Nackley, Bruce Friedman
openalex   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Integrated energy in action: Practical learnings from integrating centralized and decentralized energy delivery models in Uganda. [PDF]

iScience
Mahomed S, Shirley R, Pan CI.
europepmc   +1 more source

Optimal operational planning of hybrid power plants in railway MVDC networks and comparison with standard AC connections

Laurent Cornaggia, Robin Girard, Olivier Despouys, Hélène Clémot, Panagiotis Andrianesis   +4 more
openalex   +1 more source

Piezoelectric vibration energy harvesting: A connection configuration scheme to increase operational range and output power

, 2016
Sijun Du, Yu Jia, Ashwin A. Seshia
openalex   +2 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

An IoT-based real-time smart metering deployment for grid optimization: A case study of GEPCO, Pakistan. [PDF]

PLoS One
Saleem MU, Bajwa MHT, Rahman SU, Wen H, Khan MA.   +4 more
europepmc   +1 more source