Results 131 to 140 of about 76,908 (313)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
CSCO: Connectivity Search of Convolutional Operators
2024 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)Proceedings of the IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR) Workshops (2024)
Tunhou Zhang +5 more
openaire +2 more sources
The Normed Ordered Cone of Operator Connections
, 2013 A connection in Kubo-Ando sense is a binary operation for positive operators on a Hilbert space satisfying the monotonicity, the transformer inequality and the continuity from above. A mean is a connection $σ$ such that $A σA =A$ for all positive operators $A$.
Chansangiam, Pattrawut +1 more
openaire +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Implementation of the systems approach to improve a pharmacist-managed vancomycin dosing service. [PDF]
, 2014 PURPOSE: Quality improvements achieved by applying the systems approach to assess the clinical effectiveness, operational efficiency, and financial feasibility of a pharmacist-managed vancomycin dosing service are described. SUMMARY: Faced with increased
Roberts, Russel +2 more
core
Improving the Performance of the Keyway Connection [PDF]
, 2020 В статье рассмотрена классическая компоновка механизма передвижения кранов мостового типа, в которой передача крутящего момента от вала на полумуфту осуществляется посредствам шпоночного соединения.
Летнев, К. Ю. +2 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Consistently Using a Transportation Department for Patient Discharge to Sustain Nursing Staffing Levels [PDF]
, 2018 IMPROVING PATIENT FLOW BY UTILIZING A HOSPITAL TRANSPORTATION DEPARTMENT FOR DISCHARGES Using a transportation department for transporting patients for discharge is the industry standard. At a large urban hospital, inconsistent use of this department has
Nayak, Suneela +7 more
core +1 more source
ADVANCED 15-LEVEL INVERTER DESIGN FOR SOLAR PV INTEGRATION
Mağallaẗ Al-kūfaẗ Al-handasiyyaẗA new 15 level inverter is presented in the paper to improve the solar photovoltaic (PV) grid integration process. Improved substantially in the pattern of waves quality with the current THD 3.91%, and voltage THD to 15.77%.
E. Parimalasundar +5 more
doaj +1 more source