Results 151 to 160 of about 3,661,265 (345)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Universal Concurrent Constraint Programing: Symbolic Semantics and Applications to Security [PDF]

, 2008
International audienceWe introduce the Universal Timed Concurrent Constraint Programming (utcc) process calculus; a generalisation of Timed Concurrent Constraint Programming.
Olarte, Carlos, Valencia, Frank D.
core   +1 more source

On the spin-statistics connection in curved spacetimes

, 2015
The connection between spin and statistics is examined in the context of locally covariant quantum field theory. A generalization is proposed in which locally covariant theories are defined as functors from a category of framed spacetimes to a category ...
A. Degner, A. Higuchi, A. Schoch, C.J. Fewster, C.J. Isham, Christopher J. Fewster, CHRISTOPHER J. FEWSTER, Christopher J. Fewster, Christopher J. Fewster, Christopher J. Fewster, D. Guido, G. Lüders, H. Epstein, K. Fredenhagen, K. Sanders, K. Sanders, L. Parker, L.J. Landau, M. Fierz, N. Burgoyne, R. Brunetti, R. Brunetti, R. Haag, R.M. Wald, Rainer Verch, Rainer Verch, Romeo Brunetti, S. Doplicher, S. Hollands, S. Schlieder, S.A. Fulling, Stefan Hollands, Stefan Hollands, W. Pauli   +33 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Flight Flutter Testing of Supersonic Interceptors [PDF]

A summary is presented of experiences in connection with flight flutter testing of supersonic interceptors. The planning and operational aspects involved are described along with the difficulties encountered, and the correlation between measurement and ...
Dublin, M., Peller, R.
core   +1 more source

The connection between an event structure semantics and an operational semantics for TCSP [PDF]

, 1991
The relation between an operational interleaving semantics for TSCP based on a transition system and a compositional true concurrency semantics based on event structures is studied. In particular we extend the consistency result of U. Goltz and R. Loogen
Baier, Christel, Majster-Cederbaum, Mila
core   +1 more source

Inequalities connected with averaging operators

Indagationes Mathematicae, 2013
Abstract The purpose of the present paper is to investigate two functional inequalities with the unknown mapping acting on an ordered ring. Our investigations are motivated by the notion of averaging operators and by some earlier studies of related functional equations.
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source