Results 161 to 170 of about 2,297,961 (309)

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Bayesian Methods for Measuring Operational Risk [PDF]

The likely imposition by regulators of minimum standards for capital to cover 'other risks' has been a driving force behind the recent interest in operational risk management.
Carol Alexander
core  

Direct Molding of Luer Connections in PDMS Microfluidic Devices: Comparison with Conventional Interface Methods. [PDF]

Micromachines (Basel)
Layedra G, Vallejo Janeta AP, Gimenez R, Isa Jara R, Peñaherrera-Pazmiño AB, Mayorga-Ramos A, Rosero G, Perez MS, Lerner B.   +8 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

4th Ohio Infantry flag

, 1917
This rectangular red and blue silk flag features an embroidered eagle and gold fringe around the edges. This flag was used by the 4th Ohio Infantry during World War I between 1917 and 1918.

core  

Digital transformation as a driver of operational sustainability in manufacturing: a systematic review (2015-2025). [PDF]

F1000Res
Cruz Salinas LE, Macalopú Rimachi J, Sandoval Reyes CJ.   +2 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Ohio flag

, 1967
This flag of Ohio has seventeen white stars on a blue triangular-shaped field adjacent to red and white stripes. This swallowtail flag is made of cotton and dates from approximately 1967. During the Vietnam War, Governor James A. Rhodes sent this flag to

core  

Interactive causal diagram of habitat design impacts on behavioral health and performance in extreme environments. [PDF]

NPJ Microgravity
Lin M, Chen L, Arquilla K.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source