Results 101 to 110 of about 1,235,898 (307)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Definition of the System, Operational Design Domain, and Concept of Operation

Abstract This chapter consists of three section outlining how a description of a safety-critical system should be provided. First, we elaborate on how the Definition of the System (DoS) should be provided, ensuring a detailed description of the system for which the safety case is being presented.
Thor Myklebust, Tor Stålhane, Dorthea Mathilde Kristin Vatn   +2 more
openaire   +1 more source

Blockchain Design and Modelling [PDF]

Ontology engineering, along with semantic Web technologies, allow the semantic development and modeling of the operational flow required for blockchain design.
Sfetcu, Nicolae
core  

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Outdoor Comfort Optimization in Historic Urban Quarters: From Multisensory Approaches to Operational Strategies Under Resource Constraints

Buildings
During the transition from urban expansion to renewal, optimizing environmental comfort under resource constraints presents critical challenges. While existing research confirms that multisensory interactions critically shape environmental comfort, these
Hua Su, Hui Ma, Kang Liu
doaj   +1 more source

Modelling operator control work across traffic management domains: implications for interaction design

Cognition, Technology & Work
AbstractTraffic management in aviation, shipping, and rail transport shows similarities and dissimilarities in the work process. For example, they share the temporal aspect, but different levels of urgency in the control work set different requirements on monitoring, decisions, and actions.
Lundberg, Jonas, Nylin, Magnus, Praetorius, Gesa, Jansson, Anders A., Bång, Magnus   +4 more
openaire   +4 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A New Multi-Domain Hybrid Microgrid Design Integrating Reliability and Stability Simultaneously

IEEE Access
Dynamic failures within hybrid microgrids are often initiated from stability issues, substantially elevating the system’s overall risk alongside static failures.
Ali Azizi, Saeed Peyghami, Frede Blaabjerg   +2 more
doaj   +1 more source