Results 141 to 150 of about 1,235,898 (307)

Freeform generative design of complex functional structures

Scientific Reports
Generative machine learning is poised to revolutionise a range of domains where rational design has long been the de facto approach: where design is practically a time consuming and frustrating process guided by heuristics and intuition.
Gerald G. Pereira, David Howard, Paulus Lahur, Michael Breedon, Phil Kilby, Christian H. Hornung   +5 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Optimisation of topology, rating, control and insulation coordination of a large series–parallel DC windfarm

IET Renewable Power Generation
This study presents the design of a large DC series‐parallel windfarm that considers the key operational challenges in determining the optimal generator equipment rating and DC transmission voltage control.
Ibrahim Ahmad Shehu, Dragan Jovcic, Peng Li   +2 more
doaj   +1 more source

A Lightweight Authentication Method for Industrial Internet of Things Based on Blockchain and Chebyshev Chaotic Maps

Future Internet
The Industrial Internet of Things (IIoT), a key enabler of Industry 4.0, integrates advanced communication technologies with the industrial economy to enable intelligent manufacturing and interconnected systems.
Zhonghao Zhai, Junyi Liu, Xinying Liu, Yanqin Mao, Xinjun Zhang, Jialin Ma, Chunhua Jin   +6 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Evaluation of Remote Driver Performance in Urban Environment Operational Design Domains

IEEE Open Journal of Intelligent Transportation Systems
Remote driving has emerged as a solution for enabling human intervention in scenarios where Automated Driving Systems (ADS) face challenges, particularly in urban Operational Design Domains (ODDs).
Ole Hans, Benedikt Walter, Jurgen Adamy
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Operational design domain

Während die Nutzung von Kraftfahrzeugen stetig zunimmt, stellt die Nachfrage nach "intelligenten" Fahrzeugen eine große Herausforderung für die Hersteller dar. Mit dem Ziel, vollständig autonome Fahrzeuge zu realisieren, nehmen die Fortschritte auf dem Gebiet der Umgebungswahrnehmungssysteme und anderer Fahrerassistenzmodule stetig zu.
openaire   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source