Results 31 to 40 of about 11,767,344 (228)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Navigating the Handover: Reviewing Takeover Requests in Level 3 Autonomous Vehicles
IEEE Open Journal of Vehicular TechnologyAutonomous vehicles (AVs) represent a transformative advance in automotive technology, promising increased safety and efficiency by reducing human error.
Joel Andrew Miller +2 more
doaj +1 more source
Integrating Artificial Intelligence into Naval Capability Development [PDF]
TransNavThe rapid advancement of artificial intelligence (AI) is transforming naval capabilities, reshaping ship design, lifecycle management, operational decision-making, and autonomous maritime systems.
Andrija Ljulj +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
MachinesThe work presented in this paper is to be read within the context of a connected autonomous vehicle (CAV). This context makes it possible to consider dividing the overall operational domain (operational design domain: ODD) of the vehicle into three sub ...
Fouad Farah +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Operational design co-ordination : an agent based approach [PDF]
, 2002 Operational design co-ordination has been identified as the basis for an approach to engineering design management that is more comprehensive than those that currently exist.
Duffy, Alex H.B. +3 more
core +2 more sources
EngDeployment of Level 3 and Level 4 autonomous vehicles (AVs) in urban environments is significantly constrained by adverse weather conditions, limiting their operation to clear weather due to safety concerns.
Ramakrishnan Subramanian, Ulrich Büker
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source