Results 51 to 60 of about 11,767,344 (228)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Fractal-pyramid fractance approximation circuit—scaling extension and optimization design principle

四川大学学报. 自然科学版, 2021
Analyze the characteristics of B-type fractal-pyramid fractance approximation circuit, which has only negative half-order operational performance. According to scalingextension theory, a fractance approximation circuit with arbitrary real-order calculus ...
ZHANG Yue-Rong, GUO Zhao-Ru, YUAN Xiao
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Multi-Modal Cross-Attention-Based Multi-Label Weather and Severity Level Classification

IEEE Access
Ensuring traffic safety in autonomous vehicles requires accurate weather and severity recognition, especially when operating within a defined ODD. However, most existing studies and datasets focus on single-label weather recognition and largely overlook ...
Hyeongjin Ju, Yagiz Nalcakan, Incheol Park, Youngwan Jin, Sanghyeop Yeo, Shiho Kim   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Adaptive Operational Design Domain [PDF]

As the development of the ODD in autonomous systems continue, it becomes imperative to uphold stringent safety measures. However, the landscape of autonomous systems poses unique challenges, including the need to ensure the safety of degraded or impaired
Kees, Yannick, Mut, Ryan, Sauter, Gerald, Köster, Frank, Hallerbach, Sven   +4 more
core  

Robust design of an oscillating water column wave energy converter based on operational wave conditions

Frontiers in Energy Research
Robust design methodologies have rarely been applied to oscillating water column (OWC) wave energy converters under realistic irregular wave conditions. This study proposes a robust design framework for OWC systems based on operational wave conditions to
Jeong-Seok Kim, Yoon-Jin Ha, Su-gil Cho
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Cost Efficient and Low-Latency Network Service Chain Deployment Across Multiple Domains for SDN

IEEE Access, 2019
With the fast development of Internet, network traffic rapidly grows and the size of Internet scale gradually becomes bigger. It brings serious challenges to Network Service Chain (NSC) deployment across multiple domains which are managed by different ...
Chuangchuang Zhang, Xingwei Wang, Yong Zhao, Anwei Dong, Fuliang Li, Min Huang   +5 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source