Results 71 to 80 of about 11,767,344 (228)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Cyber Defense ReviewCyberspace has been formally recognized as a domain of warfare for over two decades, yet U.S. military doctrine and practice continue to treat it primarily as a cross-domain enabler rather than a battlespace of independent operational and strategic ...
Skyler Onken, Margaret Webber
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Vojenské rozhledyIn military operations, there is increasing emphasis on multi-domain operations (MDO) across land, sea, air, space and cyberspace, with technology and cognitive domain operations playing key roles.
Steven P. A. Hornstra +6 more
doaj +1 more source
Recherches en Éducation, 2016 This paper aims to understand the design of training in occupational risk prevention with cross-references to ergonomics and professional didactics. A case study realized in the delivery of ready-to-use concrete domain is presented.
Christine Vidal-Gomel
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A generic operational simulation for early design civil unmanned aerial vehicles
, 2011 Contemporary aerospace programmes often suffer from large cost overruns, delivery delays and inferior product quality. This is caused in part by poor predictive quality of the early design phase processes with regards to the operational environment of a ...
Takeda, Kenji +2 more
core +1 more source
Core Technologies of Sugarcane Chopper Harvester Extractor: A Critical Review
AgricultureThis review has systematically assessed the critical technologies of impurity removal fans in segmental sugarcane harvesters, highlighting their impact on minimizing harvester impurity rates.
Weiqing Li +5 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source