Results 131 to 140 of about 78,638 (313)
The Sustainability of the Regional Operational Programme Projects
, 2012 Bakalářská práce se zabývá udržitelností projektů Regionálního operačního programu regionu soudržnosti Střední Morava. Práce se skládá z teoretické a praktické části.
Reimerová, Iveta
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2010 Tato diplomová práce pojednává o důvodu vzniku a vývoji politiky hospodářské a sociální soudržnosti v EU, o tématech, které tato politika řeší a nástrojích, pomocí kterých poskytuje členským státům finanční pomoc.
Mačáková, Veronika
core
Evaluation of Subsidies in Recovery of Landscape within the Operational Programme Environment [PDF]
, 2017 Public expenses are often evaluated in terms of their effectiveness. This is caused by the character of financial resources and by the fact that public activities are dependent on those resources.
Pavla Kubová +2 more
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
The Human Resources and Employment Operational Programme - specific example
, 2016 The theoretical part is focused on characteristics of the labor market , causes and consequences of unemployment risk groups of people over 50 years , the European Social Fund and its impact on the labor market and characterized Operational Programme ...
Novotná, Jitka
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source