Results 141 to 150 of about 78,638 (313)
Operational programme for Fisheries: implementation and case study
, 2011 The diploma thesis aims to discribe the implementation of Operational programme for Fisheries and to explain how the programme works on the case study of a successful project.
Argayová, Nikol
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Evaluation of Projects Financed from the Operational Programme Human Resources and Employment
, 2012 Tato diplomová práce se zabývá evaluací projektů financovaných z Operačního programu Lidské zdroje a zaměstnanost. Je složena z teoretické a praktické části.
Havlíková, Lucie
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The Analysis of drawing subsidies from the Operational Programme Environment 2007 -2013
, 2018 Cílem práce je analyzovat strukturu využívání finančních prostředků z operačního programu Životní prostředí v programovacím období 2007-2013. V teoretické části je popsán vznik a vývoj regionální politiky EU, stručně je zmíněna enviromentální politika EU
Kašparová, Lucie
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The evolving deceased donor kidney transplantation programme in Sri Lanka: current landscape, constraints, and next steps. [PDF]
Front TransplantHewageegana A.
europepmc +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Evaluation of the Integrated Operational Programme for tourism development
, 2009 The objective of this diploma thesis is to evaluate the utilization of the Integrated operational programme for the tourism development in the Czech Republic. First part of the thesis presents basic information about the programme. Second part is focused
Kovářová, Pavlína
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source