Results 151 to 160 of about 51,144,526 (293)

New Trends regarding the Operational Risks in Financial Sector [PDF]

Risks, especially "operational risks" are part of corporate life, they are the essence of financial institutions' activities. Operational risks are complex and often interlinked and have to be managed properly.
Laura Giurca Vasilescu
core  

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Mentorship for research on TB in India: a course on Public Health Implementation Strengthening and Operational Research (MPHISOR). [PDF]

Public Health Action
Shewade HD, Manickam P, Bhatnagar T, Shringarpure K, Das M, Kalaiselvi S, Nair D, Melfha JM, Verma M, Akshaya KM, Mattoo SK, Murhekar MV.   +11 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Operational research in infectious disease outbreak response: An analysis of the World Health Organization's Disease Outbreak News. [PDF]

PLOS Glob Public Health
Rosenthal M, Stolow J, Vogt F, Barnsley H, Caine E, Garone D, Carson G, Sauer L, Del Rio Vilas V, Mullen L.   +9 more
europepmc   +1 more source

Quality of Reporting of Adverse Drug Reactions to Antimicrobials Improved Following Operational Research: A before-and-after Study in Sierra Leone (2017-2023). [PDF]

Trop Med Infect Dis, 2023
Conteh TA, Thomas F, Abiri OT, Komeh JP, Kanu A, Kanu JS, Fofanah BD, Thekkur P, Zachariah R.   +8 more
europepmc   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Addressing the need for an operational research framework for Africa. [PDF]

J Public Health Afr
Choge IA, Kamara NW, Aragaw MT, Ndembi N, Tsague LD.   +4 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Building Capacity in Institutional Operational Research in Low-Resource Settings: Protocol for an Implementation Research Study. [PDF]

JMIR Res Protoc
Ali S, Murthy GVS, Bassett KL, Reddy P, Judson K, Gilbert SS, Patra A, Gudlavalleti AG, Gudlavalleti AG, Mahapatra D, Pant H, Dakhwa P, Jameel S, Pandey SP, Tetali S, Chaudhuri S, Imandi S, Kamalakannan S.   +17 more
europepmc   +1 more source