Results 151 to 160 of about 494,728 (259)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Advancing implementation science and policy on HIV/AIDS: outcomes from the fourth edition of the Cameroon HIV operational research forum (CAM-HERO) 2024. [PDF]

Pan Afr Med J
Mabou GT, Ebasone PV, Sam-Agudu NA, Tchendjou P, Adirieje C, Tchounga B, Ndom MS, Fokam J, Ajeh R, Khan EM, Shu EN, Katayi ET, Atanga PN, Ngamani ML, Lengouh C, Nekame LG, Djikeussi T, Tene G, Chenwi C, Semengue ENJ, Chiabi E, Nasah J, Ching J, Ngo-Malabo E, Nshom E, Meka AFZ, Tchakounte BY, Ayima CW, Tumasang F, Kana R, Nka AD, Ndongo FA, Tabala FN, Noah YA, Ndie J, Ngu PN, Ketchaji A, Talla S, Edakedi MR, Banboye R, Nzeusseu HK, Ngonga L, Muffih PT, Bisseck ACZ, Dzudie A.   +44 more
europepmc   +1 more source

Developing an operational research model for strengthening policy and programs on prevention and control of hypertension in India. [PDF]

J Family Med Prim Care, 2022
Goel S.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Advancing Global Health Security through Rapid Operational Research on Diagnostics during Outbreaks. [PDF]

Am J Trop Med Hyg
Boro E, Hoppe A, Bausch DG.
europepmc   +1 more source

Operational Research to Inform Programmatic Approaches to the Management of Tuberculosis in Uzbekistan. [PDF]

Int J Environ Res Public Health, 2021
Gadoev J, Harries AD, Korotych O, Kumar AMV, Dadu A, Kuppens L, Parpieva N, Abdusamatova B, Yedilbayev A, Dara M.   +9 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Can Health Operational Research Improve Health Care in a Clinical Department? [PDF]

Acta Med Philipp
Valbuena MN.
europepmc   +1 more source

Operational Research in the University [PDF]

BMJ, 1959
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source