Results 141 to 150 of about 70,967 (306)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Computational biology approach to uncover hepatitis C virus helicase operation
World Journal of Gastroenterology, 2014 22 pages, 5 ...
openaire +4 more sources
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Solution of Some Boundary Value Problems Including Nonlinear Fractional Differential Equations
پژوهشهای ریاضی, 2020 Introduction In this paper, by mixed monotone operators and their fixed points, we investigate the existence and uniqueness of positive solution for the following boundary value problems via nonlinear fractional differential equations. and where
Hojjat Afshari, Mojtaba Sajjadmanesh
doaj
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FARM LABOR: KEY CONCEPTUAL AND MEASUREMENT ISSUES ON THE ROUTE TO BETTER FARM COST AND RETURN ESTIMATES [PDF]
This paper examines methods frequently used by agricultural economists to measure the cost of farm labor, including operator and other unpaid, and to provide insights for improving them. The tradition is broken of treating labor and management separately,
Wallace HUFFMAN
core +1 more source
Eradication Suggestions For Infectious Diseases Based on the Fractional Guinea-Worm Disease Model
Cumhuriyet Science JournalGuine-worm disease (GWD) is considered one of the most fascinating infectious diseases that almost no one is aware of. On the other hand, unfortunately, there is no medicine or vaccine to treat this tropical disease transmitted through drinking water ...
Bahar Acay Öztürk
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Astrocyte heterogeneity in brain metastases
Molecular Oncology, EarlyView.Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source