Results 131 to 140 of about 70,967 (306)
Operations research: from computational biology to sensor network.
, 2013 In this dissertation we discuss the deployment of combinatorial optimization methods for modeling and solve real life problemS, with a particular emphasis to two biological problems arising from a common scenario: the reconstruction of the three-dimensional shape of a biological molecule from Nuclear Magnetic Resonance (NMR) data.
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Evolutionary computation applied to combinatorial optimisation problems [PDF]
, 2007 This thesis addresses the issues associated with conventional genetic algorithms (GA) when applied to hard optimisation problems. In particular it examines the problem of selecting and implementing appropriate genetic operators in order to meet the ...
Mitchell, George G.
core
Kinetic equation for a gas with attractive forces as a functional equation
Annales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2009 Diffusion problems studied in the time scale comparable with time of particles collision lead to kinetic equations which for step-wise potentials are functional equations in the velocity space.
Ryszard Wojnar
doaj
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
The Barnaby Laws: A Universal Framework for Operator-Threshold Dynamics Across Domains [PDF]
Complex systems across physics, biology, linguistics, economics, and information networks exhibit strikingly similar patterns of collapse, stability, and structural organization.
Dillon Barnaby
core
Emergence in exact natural science [PDF]
, 1998 The context of an operational description is given by the distinction between what we consider as relevant and what as irrelevant for a particular experiment or observation.
Primas, Hans
core
Pragmatic turn in biology: From biological molecules to genetic content operators
World Journal of Biological Chemistry, 2014 Erwin Schrödinger's question "What is life?" received the answer for decades of "physics + chemistry". The concepts of Alain Turing and John von Neumann introduced a third term: "information". This led to the understanding of nucleic acid sequences as a natural code. Manfred Eigen adapted the concept of Hammings "sequence space".
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