Results 111 to 120 of about 70,967 (306)

Criterion of positivity for semilinear problems with applications in biology [PDF]

, 2017
International audienceThe goal of this article is to provide an useful criterion of positivity and well-posedness for a wide range of infinite dimensional semilinear abstract Cauchy problems.
Michel Duprez, Perasso, Antoine, Antoine Perasso, Duprez, Michel   +3 more
core   +1 more source

Scalable workflows for high-throughput respirometry

Life Science Alliance
In this study, we discuss the novel methodologies, approaches, and considerations required to scale mitochondrial respirometry studies for high-throughput and large sample number studies.
Corey A Osto, Eugene V Mosharov, Ayelet M Rosenberg, Martin Picard, Linsey Stiles, Orian Shirihai   +5 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Living with an imperfect cell wall: compensation of femAB inactivation in Staphylococcus aureus [PDF]

, 2007
Background: Synthesis of the Staphylococcus aureus peptidoglycan pentaglycine interpeptide bridge is catalyzed by the nonribosomal peptidyl transferases FemX, FemA and FemB.
Majcherczyk, Paul A, Andrea Jansen, Harris, Llinos G.,, Berger-Bächi, Brigitte, Gabriele Bierbaum, Bierbaum, Gabriele, Majcherczyk, Paul A.,, Hübscher, Judith,, Schäfer, Juliane,, Jansen Andrea, Schäfer, Juliane, Heinemann, Matthias,, Kotte, Oliver, Bierbaum Gabriele, Heinemann, Matthias; id_orcid, Harris, Llinos G., Hübscher, Judith, Bierbaum, Gabriele,, Judith Hübscher, Majcherczyk Paul A, Oliver Kotte, Jansen, Andrea,, Schäfer Juliane, Berger-Bächi, Brigitte,, Kotte, Oliver,, Jansen, Andrea, Brigitte Berger-Bächi, Llinos Harris, Heinemann, Matthias, Matthias Heinemann, Majcherczyk, Paul A., Heinemann Matthias, Harris, Llinos G, Llinos G Harris, Hübscher Judith, Juliane Schäfer, Kotte Oliver, Paul A Majcherczyk, Harris Llinos G, Berger-Bächi Brigitte   +39 more
core   +1 more source

Chromosome segregation dynamics during the cell cycle of Staphylococcus aureus

Nature Communications
Research on chromosome organization and cell cycle progression in spherical bacteria, particularly Staphylococcus aureus, remains limited and fragmented. In this study, we established a working model to investigate chromosome dynamics in S.
Adrian Izquierdo-Martinez, Simon Schäper, António D. Brito, Qin Liao, Coralie Tesseur, Moritz Sorg, Daniela S. Botinas, Xindan Wang, Mariana G. Pinho   +8 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Synthetic data-driven deep learning for label-free autonomous atomic force microscopy

Nature Communications
Atomic force microscopy (AFM) is a widely used tool for nanoscale characterization across materials science, energy research, and biology. However, its adoption in high-throughput materials discovery and statistically driven studies remains limited by a ...
Ruben Millan-Solsona, Marti Checa, Spenser R. Brown, Amber N. Bible, Bernadeta Srijanto, Laura Wiggins, Sita Sirisha Madugula, Alice L. B. Pyne, Jennifer L. Morrell-Falvey, Scott Retterer, Rama K. Vasudevan, Liam Collins   +11 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source