Results 91 to 100 of about 278,032 (289)
An open-source FACS automation system for high-throughput cell biology.
PLoS ONERecent advances in gene editing are enabling the engineering of cells with an unprecedented level of scale. To capitalize on this opportunity, new methods are needed to accelerate the different steps required to manufacture and handle engineered cells ...
Diane M Wiener +12 more
doaj +1 more source
A Process Algebraical Approach to Modelling Compartmentalized Biological Systems [PDF]
, 2007 This paper introduces Protein Calculus, a special modeling language designed for encoding and calculating the behaviors of compartmentilized biological systems.
Ihekwaba, Adaoha, Mardare, Radu
core +1 more source
On Kinetic Equations Modeling Evolution of Systems in Mathematical Biology
, 2013 We develop a rigorous formalism for the description of the kinetic evolution of interacting entities modeling systems in mathematical biology within the framework of the evolution of marginal observables.
Fedchun, Yu. Yu., Gerasimenko, V. I.
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
An innovative analytical method utilizing aboodh residual power series for solving the time-fractional newell-whitehead-segel equation [PDF]
Computational Algorithms and Numerical DimensionsIn this study, we use a new method called Abode Residual Power Series Method (ARPSM) to derive the analytical results of the Newell-Whitehead-Siegel equation.
Seyed Edalatpanah, Eisa Abdolmaleki
doaj +1 more source
Computational biology approach to uncover hepatitis C virus helicase operation
World Journal of Gastroenterology, 2014 22 pages, 5 ...
openaire +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Scientific ReportsDetecting protein complexes is crucial in computational biology for understanding cellular mechanisms and facilitating drug discovery. Evolutionary algorithms (EAs) have proven effective in uncovering protein complexes within networks of protein–protein ...
Mustafa N. Abbas +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source