Results 91 to 100 of about 1,844,598 (293)

A natural space of functions for the Ruelle operator theorem [PDF]

, 2007
We study a new space, $R(X)$, of real-valued continuous functions on the space $X$ of sequences of zeros and ones. We show exactly when the Ruelle operator theorem holds for such functions.
Walters, Peter
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

An open-source FACS automation system for high-throughput cell biology.

PLoS ONE
Recent advances in gene editing are enabling the engineering of cells with an unprecedented level of scale. To capitalize on this opportunity, new methods are needed to accelerate the different steps required to manufacture and handle engineered cells ...
Diane M Wiener, Emily Huynh, Ilakkiyan Jeyakumar, Sophie Bax, Samia Sama, Joana P Cabrera, Verina Todorova, Madhuri Vangipuram, Shivanshi Vaid, Fumitaka Otsuka, Yoshitsugu Sakai, Manuel D Leonetti, Rafael Gómez-Sjöberg   +12 more
doaj   +1 more source

Systems Biology Graphical Notation: Process Description language Level 1 Version 2.0

Journal of Integrative Bioinformatics, 2019
The Systems Biology Graphical Notation (SBGN) is an international community effort that aims to standardise the visualisation of pathways and networks for readers with diverse scientific backgrounds as well as to support an efficient and accurate ...
Rougny Adrien, Touré Vasundra, Moodie Stuart, Balaur Irina, Czauderna Tobias, Borlinghaus Hanna, Dogrusoz Ugur, Mazein Alexander, Dräger Andreas, Blinov Michael L., Villéger Alice, Haw Robin, Demir Emek, Mi Huaiyu, Sorokin Anatoly, Schreiber Falk, Luna Augustin   +16 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Automated Platforms in C. elegans Research: Integration of Microfluidics, Robotics, and Artificial Intelligence

Micromachines
Caenorhabditis elegans is one of the most extensively studied model organisms in biology. Its advantageous features, including genetic homology with humans, conservation of disease pathways, transparency, short lifespan, small size and ease of ...
Tasnuva Binte Mahbub, Parsa Safaeian, Salman Sohrabi   +2 more
doaj   +1 more source

Biosemiotics, code biology, and operational interpretation

Chinese Semiotic Studies
Abstract Biosemiotics and code biology are two promising approaches to understanding biological phenomena as meaningful. Biosemiotics proposes that a defining characteristic of life is code-duality, while code biology asserts that the nature of life lies in its code.
openaire   +1 more source

TarO : a target optimisation system for structural biology [PDF]

, 2008
This work was funded by the UK Biotechnology and Biological Sciences Research Council (BBSRC) Structural Proteomics of Rational Targets (SPoRT) initiative, (Grant BBS/B/14434).
Naismith, Jim, Barton, Geoffrey J, Naismith, James H, William N. Hunter, White, Malcolm F, McMahon, Stephen, Hunter, William N., vanNiekerk, C. A. Johannes, Overton, Ian M., Hunter, William, van Niekerk, C. A. Johannes, van Niekerk, C A, Barton, Geoffrey, Carter, Lester, Geoffrey J. Barton, Naismith, James, Hunter, W N, Carter, Lester G., Overton, Ian; id_orcid, Dawson, Alice, McMahon, S A, Dawson, A, David M. A. Martin, McMahon, Stephen A., White, Malcolm F., Martin, David, Scott Cameron, White, Malcolm, Barton, G J, Cameron, Scott, Naismith, James H., Ian M. Overton, James H. Naismith, Cameron, S, Malcolm F. White, Barton, Geoffrey J.; id_orcid, Lester G. Carter, Carter, L G, Alice Dawson, Martin, D M, Martin, David M. A.; id_orcid, C. A. Johannes Van Niekerk, Stephen A. Mcmahon, Overton, I M, Overton, Ian   +44 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source