Results 71 to 80 of about 70,967 (306)

Degenerate Diffusion Operators Arising in Population Biology

open access: yes, 2011
We analyze a class of partial differential equations that arise as "backwards Kolmogorov operators" in infinite population limits of the Wright-Fisher models in population genetics and in mathematical finance. These are degenerate elliptic operators defined on manifolds with corners. The classical example is the Kimura diffusion operator, which acts on
Epstein, Charles L., Mazzeo, Rafe
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Isolation and Characterization of Novel Insertional Mutants in the Early Region 1A of Adenovirus Type 5 [PDF]

open access: yes, 1989
The early region 1A (E1A) of adenovirus 5 codes for oncoproteins whose functions are central to the life cycle of the virus. Its involvement in the initiation of the oncogenic transformation process has been a subject of intense study to understand the ...
Bautista, Diosdado S.
core  

Building nearest prototype classifiers using a Michigan approach PSO [PDF]

open access: yes, 2007
IEEE Swarm Intelligence Symposium. Honolulu, HI, 1-5 april 2007This paper presents an application of particle swarm optimization (PSO) to continuous classification problems, using a Michigan approach. In this work, PSO is used to process training data to
Galván, Inés M.   +8 more
core   +1 more source

An Evolutionary Algorithm With Heuristic Operator for Detecting Protein Complexes in Protein Interaction Networks With Negative Controls

open access: yesIEEE Access
Computational biology research faces a formidable challenge in the detection of complexes within protein-protein interaction (PPI) networks, critical for unraveling cellular processes, predicting functions of uncharacterized proteins, and diagnosing ...
Mustafa N. Abbas   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Concrete and Formal Operational Thought: Implications for Introductory College Biology [PDF]

open access: yesThe American Biology Teacher, 1976
THE COGNITIVE ABILITIES of concrete operational and formal operational thinkers, as defined by the Swiss psychologist Jean Piaget, have received a great deal of attention in recent years. This article briefly describes the stages involved in Piaget's model and reviews the current literature as it applies to Piaget's ideas and specifically to students ...
Suzanne B. Haley, Ronald G. Good
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

ANERIS: Towards a network of Operational Marine Biology

open access: yes
This is the presentation given at the session: “Biodiversity Observatory: Smart Systems for a Living Planet – Revolutionising Biodiversity Monitoring with Automation” at the BEeS conference 2025. We want to acknowledge the ANERIS consortium for their contributions. 
Companys, Berta   +6 more
openaire   +4 more sources

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