Results 71 to 80 of about 2,135,480 (327)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Selection of key sequence-based features for prediction of essential genes in 31 diverse bacterial species. [PDF]
PLoS ONE, 2017 Genes that are indispensable for survival are essential genes. Many features have been proposed for computational prediction of essential genes. In this paper, the least absolute shrinkage and selection operator method was used to screen key sequence ...
Xiao Liu +4 more
doaj +1 more source
Automated High-Throughput Microchannel Assays for Cell Biology: Operational Optimization and Characterization [PDF]
JALA: Journal of the Association for Laboratory Automation, 2010 Screening biological readouts in cell culture are increasing in frequency and throughput. In such assays, cell types may be rare and reagents or compounds may be expensive often resulting in a reduced number of conditions and/or replicates. “Tubeless” microfluidics offers a method to reduce this burden, as has been previously shown. In addition the In-
John P, Puccinelli +2 more
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Fractal and Fractional, 2023 This work provides exact and analytical approximate solutions for a non-linear time-fractional generalized biology population model (FGBPM) with suitable initial data under the time-Caputo fractional derivative, in view of a novel effective and ...
Mohammad Alaroud +3 more
doaj +1 more source
Multiscale Modeling in Systems Biology: Methods and Perspectives
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, 2021 In the last decades, mathematical and computational models have become ubiquitous to the field of systems biology. Specifically, the multiscale nature of biological processes makes the design and simulation of such models challenging.
A. Coulier
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Boundary value problems for systems of non-degenerate difference-algebraic equations
Visnik Harkivsʹkogo Nacionalʹnogo Universitetu im. V.N. Karazina. Cepiâ Matematika, Prikladna Matematika i Mehanika, 2019 The study of differential-algebraic boundary value problems was initiated in the works of K. Weierstrass, N.N. Luzin and F.R. Gantmacher. Systematic study of differential-algebraic boundary value problems is devoted to the work of S.
Sergey Chuiko +2 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
On Fractional-Order Discrete-Time Reaction Diffusion Systems
Mathematics, 2023 Reaction–diffusion systems have a broad variety of applications, particularly in biology, and it is well known that fractional calculus has been successfully used with this type of system.
Othman Abdullah Almatroud +3 more
doaj +1 more source