Results 101 to 110 of about 442,383 (279)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Orlicz norm inequalities for the composite operator and applications

open access: yesJournal of Inequalities and Applications, 2011
In this article, we first prove Orlicz norm inequalities for the composition of the homotopy operator and the projection operator acting on solutions of the nonhomogeneous A-harmonic equation.
Ding Shusen, Bi Hui
doaj  

Notes on the Propagators of Evolution Equations

open access: yesAdvances in Difference Equations, 2010
We consider the propagator of an evolution equation, which is a semigroup of linear operators. Questions related to its operator norm function and its behavior at the critical point for norm continuity or compactness or differentiability are studied.
Jin Liang, Yu Lin, Ti-Jun Xiao
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

INTERPOLATION WITH MINIMUM VALUE OF \(L_{2}\)-NORM OF DIFFERENTIAL OPERATOR

open access: yesUral Mathematical Journal
For the class of bounded in \(l_{2}\)-norm interpolated data, we consider a problem of interpolation on a finite interval  \([a,b]\subset\mathbb{R}\) with minimal value of the \(L_{2}\)-norm of a differential operator applied to interpolants ...
Sergey I. Novikov
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

Tetris Tight Frames Construction via Hadamard Matrices

open access: yesAbstract and Applied Analysis, 2014
We present a new method to construct unit norm tight frames by applying altered Hadamard matrices. Also we determine an elementary construction which can be used to produce a unit norm frame with prescribed spectrum of frame operator.
A. Abdollahi, M. Monfaredpour
doaj   +1 more source

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