Results 111 to 120 of about 135,056 (273)
In Salmonella Typhimurium, YiiD Modulates cAMP Levels in Lag Phase During Growth on Succinate
Molecular Microbiology, EarlyView.The YiiD enzyme, found by others to perform a redundant role in fatty acid biosynthesis, is found to be unexpectedly required for the early increase in cAMP in lag phase during growth on succinate. This intriguing finding suggests a mechanistic link may exist between fatty acid biosynthesis and catabolite repression. ABSTRACT In Salmonella Typhimurium (
John A. Ciemniecki +2 more
wiley +1 more source
Molecular Microbiology, EarlyView.Host tissue cues including temperature, oxygen, and iron availability regulate expression of the Yersinia type III secretion system (T3SS) master regulator LcrF. We found that CpxR inhibits LcrF through an indirect, multi‐factorial mechanism and identified the osmolarity‐sensing OmpR/EnvZ system as an additional regulator of LcrF, highlighting ...
Karen Hug +8 more
wiley +1 more source
Self-assembly of Escherichia coli phage shock protein A
, 2014 The Phage shock protein (Psp) response is an extracytoplasmic stress response. The central component of this system is PspA, a protein that mediates the physiological response to membrane stress.
Male, Abigail, Tavassoli, Ali
core +1 more source
Molecular Microbiology, EarlyView.Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan +2 more
wiley +1 more source
Molecular Microbiology, EarlyView.Unlike the wild‐type BW25113, the fis null mutant is characterized by biphasic growth at 12°C. During the first phase of growth, the absence of FIS results in the formation of filaments with dispersed nucleoids. During the acclimation phase, the FIS Null Adaptation Response is activated that leads to an increase in cell division and nucleoid ...
Pamela G. Jones
wiley +1 more source
Tools for characterization of Escherichia coli genes of unknown function
, 2002 Despite the power of sequencing and of emerging high-throughput technologies to collect data rapidly, the definitive functional characterization of unknown genes still requires biochemical and genetic analysis in case-by-case studies. This often involves
Masters, Millicent +3 more
core +1 more source
Molecular Microbiology, EarlyView.The metabolism of ribose starts with the phosphorylation of its 5′ hydroxyl group. Salmonella typhimurium has two kinases that perform this function, namely ribose rinase (RbsK) and deoxyribose kinase (DeoK). Here we report a new ribose kinase that we named RikA. The illustration was partially created in BioRender.
Regan D. McCormick +2 more
wiley +1 more source
Transcriptome dynamics-based operon prediction in prokaryotes
, 2014 Background Inferring operon maps is crucial to understanding the regulatory networks of prokaryotic genomes. Recently, RNA-seq based transcriptome studies revealed that in many bacterial species the operon structure vary with the change ...
Smolander, Olli-Pekka +10 more
core +1 more source
To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility
Molecular Microbiology, EarlyView.Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh +2 more
wiley +1 more source