Results 231 to 240 of about 135,056 (273)

Polarity in the histidine operon

Journal of Molecular Biology, 1966
Abstract Sixty-eight mutants in the C gene of the histidine operon in Salmonella typhimurium have been examined for polarity. All nonsense and frameshift mutants were found to be polar, whereas none of the missense mutants exhibited polarity. The mutants mapping on the side of the C cistron towards the operator region were more strongly polar ...
R G, Martin, D F, Silbert, W E, Smith, H J, Whitfield   +3 more
openaire   +2 more sources

The Structure of the mer Operon

1985
The DNA sequence has been determined for a 3.8-kb region which encodes the mercury-resistance (mer) operon of the IncFII plasmid NR1. The sequence reveals 4 open reading frames which could encode proteins of 12,522, 9,429, 14,965, and 58,912 d corresponding to the 4 previously described Hg-inducible proteins detected in minicells carrying mer+ plasmids.
P, Barrineau, P, Gilbert, W J, Jackson, C S, Jones, A O, Summers, S, Wisdom   +5 more
openaire   +2 more sources

Regulation of the lactose operon in vitro

Molecular and General Genetics MGG, 1970
Using DNA of phage ϕ80p lac carrying lac-operon (i+o+z+y+), the transcription of the lac-operon was studied in vitro. The lac-specific mRNA having a molecular size of 28S was detected by hybridizing messenger RNA (mRNA) from induced cells (diploid for the lac-operon) to the ϕ80p lac DNA. The hybridization of lac-specific mRNA to ϕ80p lac DNA was almost
Y, Iida, T, Kameyama, Y, Oshima, T, Horiuchi   +3 more
openaire   +2 more sources

Operon prediction by Markov clustering

International Journal of Data Mining and Bioinformatics, 2014
The prediction of operons is a critical step for the reconstruction of biochemical and regulatory networks at the whole genome level. In this paper, a novel operon prediction model is proposed based on Markov Clustering (MCL). The model employs a graph-clustering method by MCL for prediction and does not need a classifier.
W. Du, Z. Cao, Y. Wang, Blanzieri, Enrico, C. Zhang, Y. Liang   +5 more
openaire   +2 more sources

Allostery and the lac Operon

Journal of Molecular Biology, 2013
The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
openaire   +2 more sources

microRNAs and the Operon Paper

Journal of Molecular Biology, 2011
The "Operon paper" by F. Jacob and J. Monod started 50 years of research into understanding how the expression of genes is regulated on a molecular level. Ten years ago, microRNAs (miRNAs) emerged as major regulators of eukaryotic gene expression. Here, I will review the basic principles of gene regulation by miRNAs and how these principles can be ...
openaire   +2 more sources

Improved BioCyc Operon Prediction: Revisiting the Operon Prediction Problem

Abstract Introduction Operon prediction is a valuable component of microbial-genome annotation because operon organization can yield inferences about gene function, and because knowledge of operon structure can aid the interpretation of gene expression data.
Peter E. Midford, John Cadigan, Peter D. Karp   +2 more
openaire   +2 more sources

Operons

2006
David Hames, Nigel Hooper
openaire   +2 more sources

The operon of

FEMS Microbiology Letters, 2004
R SCHMITZ, G DIEKERT
openaire   +1 more source

Designing Biological Circuits: Synthetic Biology Within the Operon Model and Beyond

Annual Review of Biochemistry, 2021
Max A English, Raphaël V Gayet, James J Collins   +2 more
exaly