Results 161 to 170 of about 3,065,508 (250)

TRANSDERMAL, MUCOSAL, PULMONARY, AND OPHTHALMIC DRUG DELIVERY SYSTEMS: PRINCIPLES, TECHNOLOGIES, AND RECENT ADVANCES

Drug delivery systems have evolved significantly beyond conventional oral and injectable routes to improve therapeutic efficacy, patient compliance, and targeted drug action. Transdermal, mucosal, pulmonary, and ophthalmic drug delivery systems represent
Gunjan Limani
core   +1 more source

Simultaneous acquisition of maternal and dual‐fetal electrocardiography with maternal haemodynamic monitoring in anaesthetized pregnant rats

Experimental Physiology, EarlyView.
Abstract Experimental approaches that acquire maternal haemodynamics together with direct cardiac signals from more than one fetus remain limited. We developed a standardized in vivo method for simultaneous acquisition of maternal ECG, maternal arterial blood pressure and ECGs from two fetuses in anaesthetized late‐gestation Sprague–Dawley rats.
Sarah Pribil Pardun, Spencer Duff, Payton Ward, Auspy Li, Lie Gao   +4 more
wiley   +1 more source

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Environment-Dependent UV Response of Cyclosporin A in Buffered Aqueous Media: Implications for Reliable Quantitative Analysis in Ophthalmic Drug-Delivery Research. [PDF]

Pharmaceutics
Nowak I, Michałkiewicz O, Rykowska I, Nowak R.   +3 more
europepmc   +1 more source

Restoration of neuromuscular function by mitochondrial transplantation in injured mouse skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Mice received chemical injury (cardiotoxin) in the tibialis anterior muscle of one limb, and the contralateral muscle was injected with phosphate‐buffered saline (PBS) as a sham control. Mice then received PBS or mitochondria suspended in PBS into the tail vein.
Stephen E. Alway, Peter J. Ferrandi, Hector G. Paez, Christopher R. Pitzer, Junaith S. Mohamed, Michael R. Deschenes, James A. Carson   +6 more
wiley   +1 more source

Innovative PLA or PCL‐Based Ocular Implants Obtained From Tape Casting or Electrospinning for Sustained‐Release Dexamethasone

Journal of Applied Polymer Science, Volume 143, Issue 43, November 15, 2026.
PLA and PCL ocular implants prepared by tape casting and electrospinning provide sustained dexamethasone release with distinct release profiles governed by polymer type and processing method. The relationship between polymer structure, degradation behavior, and drug release demonstrates the potential of these fabrication techniques for controlled ...
Renata Bochanoski, Henrique Borba Modolon, Ronaldo Silveira, Januara Rodrigues, Tiago Bender Wermuth, Sabrina Arcaro, Oscar R. K. Montedo   +6 more
wiley   +1 more source

Advances in dry eye disease: from immunopathological mechanisms to emerging ophthalmic drug delivery systems. [PDF]

Front Med (Lausanne)
Yang N, Mu J, Xu F, Guo W, Sun C, Peng B, Xiang J, Deng L, Fan W.   +8 more
europepmc   +1 more source

Hydrogels for ophthalmic drug delivery

, 2020
La baixa penetració dels fàrmacs dins de l’ull, causada per les seves barreres morfològiques i per la ràpida excreció dels mateixos a través de l’aparell lacrimal, és necessari trobar una altra manera de instil·lar fàrmacs tòpics a l’ull. Una opció que ha estat considerada per al subministrament de fàrmacs per via tòpica són els hidrogels.
openaire   +1 more source

Biomaterials in Ophthalmic Drug Delivery

, 1996
Polymer-based biomaterials are becoming increasingly important in ophthalmology as the number of polymers available for medical devices increases. Ocular drug delivery systems based on polymers offer the considerable advantages of improving drug availability and decreasing side effects compared to conventional therapeutic methods.
Sintzel, Martina Barbara, Bernatchez, Stéphanie, Tabatabay, Cyrus A., Gurny, Robert   +3 more
openaire   +1 more source