Ophthalmic Drug Delivery Systems : An Update
Delhi Journal of Ophthalmology, 2011 Drugs developed and approved for systemic disease are reinvestigated for ocular disease. However, developing new drugs with good intraocular penetration by considering the anatomical and physiological constraints exerted by the various barriers of eye is
Nihar Ranjan Biswas
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Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. [PDF]
, 2017 PurposePharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders.
Felix, Christian M +3 more
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Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases
Pharmaceutics, 2021 Effective drug delivery to intraocular tissues remains a great challenge due to complex anatomical and physiological barriers that selectively limit the entry of drugs into the eye.
Jose Navarro-Partida +5 more
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Water dispersible microbicidal cellulose acetate phthalate film [PDF]
, 2003 BACKGROUND: Cellulose acetate phthalate (CAP) has been used for several decades in the pharmaceutical industry for enteric film coating of oral tablets and capsules.
A Robert Neurath +57 more
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DNA nanoparticles for ophthalmic drug delivery [PDF]
Biomaterials, 2018 Nucleic acids represent very appealing building blocks for the construction of nano-scaled objects with great potential applications in the field of drug delivery where multifunctional nanoparticles (NPs) play a pivotal role. One opportunity for DNA nanotechnology lies in the treatment of ophthalmic diseases as the efficacy of eye drops is impaired by ...
de Vries, Jan Willem +8 more
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Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses
Journal of Pharmacy & Pharmaceutical Sciences, 2015 Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue.
Andreza Maria Ribeiro +2 more
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Diffusion through the ex vivo vitreal body - bovine, porcine, and ovine models are poor surrogates for the human vitreous [PDF]
, 2018 © 2018 The Authors. Published by Elsevier B.V.The human vitreous humour is a complex gel structure whose composition and physical properties can vary considerably from person to person and also change with age. To date, the viscoelastic properties of the
Brown, Marc +4 more
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Recent Advances in Ophthalmic Drug Delivery [PDF]
Therapeutic Delivery, 2010 Topical ocular drug bioavailability is notoriously poor, in the order of 5% or less. This is a consequence of effective multiple barriers to drug entry, comprising nasolacrimal drainage, epithelial drug transport barriers and clearance from the vasculature in the conjunctiva.
Uday B, Kompella +2 more
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Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane
Scientific Reports, 2021 Intraocular antibiotic delivery is an important technique to prevent bacterial infection after ophthalmic surgery, such as cataract surgery. Conventional drug delivery methods, such as antibiotic eye drops, have limitations for intraocular drug delivery ...
Dong Ju Kim +6 more
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The role of Computer Aided Process Engineering in physiology and clinical medicine [PDF]
, 2009 This paper discusses the potential role for Computer Aided Process Engineering (CAPE) in developing engineering analysis and design approaches to biological systems across multiple levels—cell signalling networks, gene, protein and metabolic networks ...
Allen, R., Bogle, I.D.L., Sumner, T.
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