Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma [PDF]
, 2015 PURPOSE:To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal injection as a potential candidate for retinoblastoma treatment.METHODS:A panel of two ...
Abramson, David +13 more
core +2 more sources
Ophthalmic Drug Delivery Systems : An Update
Delhi Journal of Ophthalmology, 2011 Drugs developed and approved for systemic disease are reinvestigated for ocular disease. However, developing new drugs with good intraocular penetration by considering the anatomical and physiological constraints exerted by the various barriers of eye is
Nihar Ranjan Biswas
doaj +1 more source
Lipid-Based Nanocarriers as Topical Drug Delivery Systems for Intraocular Diseases
Pharmaceutics, 2021 Effective drug delivery to intraocular tissues remains a great challenge due to complex anatomical and physiological barriers that selectively limit the entry of drugs into the eye.
Jose Navarro-Partida +5 more
doaj +1 more source
DNA nanoparticles for ophthalmic drug delivery [PDF]
Biomaterials, 2018 Nucleic acids represent very appealing building blocks for the construction of nano-scaled objects with great potential applications in the field of drug delivery where multifunctional nanoparticles (NPs) play a pivotal role. One opportunity for DNA nanotechnology lies in the treatment of ophthalmic diseases as the efficacy of eye drops is impaired by ...
de Vries, Jan Willem +8 more
openaire +3 more sources
The parallel lives of polysaccharides in food and pharmaceutical formulations [PDF]
, 2015 The present opinion article discusses how polysaccharide structures can be used in both food and pharmaceutical formulations. We distinguish two regions depending on moisture content where polysaccharides form structures with distinct functional ...
Kontogiorgos, Vassilis +2 more
core +1 more source
Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses
Journal of Pharmacy & Pharmaceutical Sciences, 2015 Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue.
Andreza Maria Ribeiro +2 more
doaj +1 more source
Recent Advances in Ophthalmic Drug Delivery [PDF]
Therapeutic Delivery, 2010 Topical ocular drug bioavailability is notoriously poor, in the order of 5% or less. This is a consequence of effective multiple barriers to drug entry, comprising nasolacrimal drainage, epithelial drug transport barriers and clearance from the vasculature in the conjunctiva.
Uday B, Kompella +2 more
openaire +2 more sources
Corticosteroid implants for chronic non-infectious uveitis. [PDF]
, 2016 BACKGROUND: Uveitis is a term used to describe a heterogeneous group of intraocular inflammatory diseases of the anterior, intermediate, and posterior uveal tract (iris, ciliary body, choroid).
Brady, Christopher J +7 more
core +2 more sources
Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders. [PDF]
, 2017 PurposePharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders.
Felix, Christian M +3 more
core +2 more sources
Moxifloxacin releasing intraocular implant based on a cross-linked hyaluronic acid membrane
Scientific Reports, 2021 Intraocular antibiotic delivery is an important technique to prevent bacterial infection after ophthalmic surgery, such as cataract surgery. Conventional drug delivery methods, such as antibiotic eye drops, have limitations for intraocular drug delivery ...
Dong Ju Kim +6 more
doaj +1 more source