Results 11 to 20 of about 10,563 (177)

Clinical application of cone beam CT in intensity-modulated radiotherapy for the moderate to severe thyroid-associated ophthalmopathy. [PDF]

J Appl Clin Med Phys
Abstract Background Cone beam CT (CBCT) has been reported for intensity‐modulated radiation therapy (IMRT) of various cancers due to its real‐time imaging capabilities, but studies on its application in orbital diseases, particularly moderate to severe thyroid‐associated ophthalmopathy (TAO), remain limited.
Kang D, Hu H, Ma S, Bin S.
europepmc   +2 more sources

The Diagnostic Value of Mean Apparent Propagator-MRI in Dysthyroid Optic Neuropathy: A Quantitative Analysis of the Entire Visual Pathway. [PDF]

CNS Neurosci Ther
The diagnostic model combining orbital and intracranial MAP‐MRI parameters could significantly optimize diagnostic efficiency of dysthyroid optic neuropathy. Comprehensive MAP‐MRI parameters analysis of the entire visual pathway enables a deeper understanding of disease involvement, provides novel insights into the early accurate diagnosis and ...
Zou M, Wu D, Cheng Y, Qin H, Yang Z, Hong S, Zhu H, Yan C.   +7 more
europepmc   +2 more sources

Glymphatic System Dysfunction in Thyroid-Associated Ophthalmopathy: A Multimodal MRI Study. [PDF]

CNS Neurosci Ther
TAO patients exhibit impaired glymphatic function, with reduced DTI‐ALPS indices and gBOLD‐CSF coupling, but unchanged choroid plexus volume. These alterations correlate with neuropsychological symptoms and sleep disturbances. Restoring glymphatic activity may offer a therapeutic approach to enhance patient outcomes.
Zhang L, Yao J, Qi Y, Luo Y, Liu J.
europepmc   +2 more sources

Effect of orbital fat decompression on eyelid contour according to midpupil lid distance in graves' ophthalmopathy. [PDF]

BMC Ophthalmol
Wang YW, Huang WL, Liao SL, Wei YH.
europepmc   +3 more sources

Retinal Capillary Density Reduction Contributes to Dysthyroid Optic Neuropathy via an L‐Arginine‐NO Pathway: A Metabonomics and Clinical Trial Study

MedComm, Volume 7, Issue 3, March 2026.
Oxidative stress induces endothelial nitric oxide synthase (eNOS) uncoupling and L‐arginine depletion, reducing nitric oxide (NO) bioavailability in vascular endothelium and contributing to decreased retinal capillary density (RCD) in dysthyroid optic neuropathy (DON).
Yunhai Tu, Congcong Yan, Lu Chen, Weijie Liu, Xiaozhou Hu, Mengyuan Gao, Wei Rao, Jiayi Zhang, Junye Zhu, Hui Wu, Kang Zhang, Meng Zhou, Wencan Wu   +12 more
wiley   +1 more source

Cranial Nerve Involvement With Diplopia as Presenting Feature of CMT1H Caused by Recurring FBLN5 Variant

Journal of the Peripheral Nervous System, Volume 31, Issue 1, March 2026.
ABSTRACT Background and Aims CMT1H is a rare, autosomal dominant, demyelinating subtype of CMT caused by variants in FBLN5. Symptomatic cranial nerve involvement has never been reported in patients with CMT1H. Case Report We report a 45‐year‐old woman with a history of long‐standing diplopia.
Georgios Koutsis, Zoi Kontogeorgiou, Charalampos Tzempetzis, Nikolaos Ragazos, Evgenia Efthymiou, Chrisoula Kartanou, Chrysoula Koniari, Nikolaos Giagkou, Klio Chatzistefanou, Georgios Velonakis, Georgia Karadima, Vasiliki Zouvelou   +11 more
wiley   +1 more source

Anatomopathological Characterization of the Main Ocular Lesions in Green Turtles (Chelonia mydas) Along the Northern Coast of Bahia, Brazil

Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.
ABSTRACT Objective This study aimed to identify and report ophthalmic and adnexal diseases found in specimens of the Green sea turtle (Chelonia mydas). Animal Studied and Procedures Thirty‐nine animals stranded on the beaches of the north coast of Bahia, Brazil were submitted to necropsy.
Danielle Nascimento Silva, José Luís Catão‐Dias, Wendell Marcelo de Souza Perinotto, Matheus Vilardo Loés Moreira, Nayone Lantyer‐Araujo, Pedro Enrique Navas Suárez, Gustavo Rodamilans Macedo, Thaís Pires, Arianne Pontes Oriá, Alessandra Estrela‐Lima   +9 more
wiley   +1 more source

Teprotumumab for Thyroid Eye Disease: Efficacy and Impact on Orbital Decompression Utilization

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 1, February 2026.
Teprotumumab has been proven effective in thyroid eye disease and associated exophthalmos management. Since its FDA approval in 2020, teprotumumab therapy has been a popular choice for managing exophthalmos which has resulted in decreased utilization of orbital decompression surgery, from 36.8% between 2015 and 2020 to 11.1% TED patients between 2020 ...
Nitish Kumar, Pedro Lança Gomes, Gaurav Jategaonkar, Michael J. Marino, Amar Miglani, Devyani Lal   +5 more
wiley   +1 more source

Exploring tear fluid biomarkers and the ocular surface in thyroid eye disease

Acta Ophthalmologica, Volume 104, Issue 1, Page e28-e38, February 2026.
Abstract Purpose To examine ocular surface changes and inflammatory tear fluid biomarkers in patients with thyroid eye disease (TED). Methods We included 106 Graves' disease (GD) patients (36 without TED, 32 with active and 38 with inactive TED) and 106 age‐ and sex‐matched healthy subjects for ophthalmological evaluation, including ocular surface ...
Mikael Thomassen Neset, Roy Miodini Nilsen, Kristian Løvås, Kathrine Halsøy, Håkon Reikvam, Ann‐Elin Meling Stokland, Grethe Åstrøm Ueland, Anette S. B. Wolff, Hans Christian D. Aass, Sjur Reppe, Eystein Sverre Husebye, Eyvind Rødahl, Tor Paaske Utheim, Hans Olav Ueland   +13 more
wiley   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source