Results 71 to 80 of about 13,315 (221)
Therapeutic Targeting of the IGF Axis
Cells, 2019 The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease.
Eliot Osher, Valentine M. Macaulay
doaj +1 more source
International Journal of Endocrinology, Volume 2026, Issue 1, 2026.Background Thyroid eye disease (TED) is an autoimmune inflammatory condition linked to thyroid dysfunction, which can result in disfigurement and potential vision loss. Recently, immunomodulatory therapies such as rituximab have demonstrated potential benefit in managing TED.
Ming Lu +3 more
wiley +1 more source
Journal of Ophthalmology, Volume 2026, Issue 1, 2026.Purpose The conversion rate of ocular myasthenia gravis (OMG) to generalized myasthenia gravis (GMG) lacks definitive predictors. Methods This retrospective cohort study analyzed data collected at Siriraj Hospital between January 2007 and December 2019 to identify factors influencing OMG generalization and the time to conversion. The records of 200 OMG
Wanicha Chuenkongkaew +7 more
wiley +1 more source
Cross-sectional study of thyroid associated orbitopathy in a South African thyroid clinic
Journal of the Colleges of Medicine of South AfricaBackground: Thyroid-associated ophthalmopathy (TAO) is a common and debilitating manifestation of Graves’ disease (GD) associated with poor clinical outcomes including impaired quality-of-life (QoL) and socio-economic status.
Sandra De Vasconcelos +3 more
doaj +1 more source
Selenium improves mild Graves’Orbitopathy: a randomized, double-blind, placebo-controlled study. [PDF]
, 2011 Background Free oxygen radicals and cytokines play a pathogenic role in Graves’ orbitopathy (GO). This study reports the results of a randomized, double-blind, placebo-controlled trial on the effect of selenium, an antioxidant agent, or pentoxifylline ...
ALTEA, MARIA ANTONIETTA
core
Building the case for insulin-like growth factor receptor-I involvement in thyroid-associated ophthalmopathy [PDF]
, 2017 The pathogenesis of orbital Graves' disease (GD), a process known as thyroid-associated ophthalmopathy (TAO), remains incompletely understood. The thyrotropin receptor (TSHR) represents the central autoantigen involved in GD and has been proposed as the ...
Janssen, J.A.M.J.L. (Joop) +1 more
core +4 more sources
The thyroid, the eyes and the gut: a possible connection [PDF]
, 2017 Graves’ disease (GD) is an autoimmune disorder responsible for 60–90% of thyrotoxicosis, with an incidence of 1 to 2 cases per 1000 population per year in England.
Covelli, D., Ludgate, Marian Elizabeth
core +2 more sources
Eye &ENT Research, Volume 3, Issue 1, Page 1-4, March 2026.No abstract is available for this article.
wiley +1 more source
Advanced Science, Volume 12, Issue 45, December 4, 2025.This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng +14 more
wiley +1 more source
Association between copy number variation of complement component C4 and Graves' disease [PDF]
, 2011 Background Gene copy number of complement component C4, which varies among individuals, may determine the intrinsic strength of the classical complement pathway.
Yu-Huei Liu +7 more
core +2 more sources