Results 51 to 60 of about 6,900 (178)

Thyroid-associated Ophthalmopathy

Türk Oftalmoloji Dergisi, 2017
Thyroid-associated ophthalmopathy is the most frequent extrathyroidal involvement of Graves' disease but it sometimes occurs in euthyroid or hypothyroid patients. Thyroid-associated ophthalmopathy is an autoimmune disorder, but its pathogenesis is not completely understood.
Esra Şahlı, Kaan Gündüz
openaire   +3 more sources

Teprotumumab for Thyroid Eye Disease: Efficacy and Impact on Orbital Decompression Utilization

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 1, February 2026.
Teprotumumab has been proven effective in thyroid eye disease and associated exophthalmos management. Since its FDA approval in 2020, teprotumumab therapy has been a popular choice for managing exophthalmos which has resulted in decreased utilization of orbital decompression surgery, from 36.8% between 2015 and 2020 to 11.1% TED patients between 2020 ...
Nitish Kumar, Pedro Lança Gomes, Gaurav Jategaonkar, Michael J. Marino, Amar Miglani, Devyani Lal   +5 more
wiley   +1 more source

Exploring tear fluid biomarkers and the ocular surface in thyroid eye disease

Acta Ophthalmologica, Volume 104, Issue 1, Page e28-e38, February 2026.
Abstract Purpose To examine ocular surface changes and inflammatory tear fluid biomarkers in patients with thyroid eye disease (TED). Methods We included 106 Graves' disease (GD) patients (36 without TED, 32 with active and 38 with inactive TED) and 106 age‐ and sex‐matched healthy subjects for ophthalmological evaluation, including ocular surface ...
Mikael Thomassen Neset, Roy Miodini Nilsen, Kristian Løvås, Kathrine Halsøy, Håkon Reikvam, Ann‐Elin Meling Stokland, Grethe Åstrøm Ueland, Anette S. B. Wolff, Hans Christian D. Aass, Sjur Reppe, Eystein Sverre Husebye, Eyvind Rødahl, Tor Paaske Utheim, Hans Olav Ueland   +13 more
wiley   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition (Adv. Sci. 4/2026)

Advanced Science, Volume 13, Issue 4, 19 January 2026.
An Allosteric Strategy for Thyroid Eye Disease This illustration depicts an aptamer (purple) binding to the target protein (white) at an allosteric site. This strategic binding induces a conformational change that acts as a shield, preventing pathogenic autoantibodies (red) from initiating the disease cascade, while leaving the protein's normal ...
Yanchen Zhang, Ende Wu, Weibin Liu, Ling Zeng, Neng Ling, Hongmei Wang, Zhixing Li, Shuang Yao, Tonghe Pan, Xuanwen Li, Yate Huang, Xiaojing Li, Yunhai Tu, Wentao Yan, Jianzhang Wu, Mao Ye, Wencan Wu   +16 more
wiley   +1 more source

Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review

Clinical Ophthalmology, 2015
Thayalini Shanmuganathan,1 Christian Girgis,2 Hooshang Lahooti,1 Bernard Champion,1 Jack R Wall1 1Department of Medicine, Nepean Clinical School, Nepean Hospital, The University of Sydney, Sydney, 2Department of Medicine, Westmead Millennium Institute ...
Shanmuganathan T, Girgis C, Lahooti H, Champion B, Wall JR   +4 more
doaj  

Analysis of research hotspots and trends in pediatric ophthalmopathy based on 10 years of WoSCC literature

Frontiers in Pediatrics
BackgroundOphthalmopathy occurring in childhood can easily lead to irreversible visual impairment, and therefore a great deal of clinical and fundamental researches have been conducted in pediatric ophthalmopathy.
Qianfang Jia, Qianfang Jia, Xiaofang Wang, Xiwan Li, Cuijuan Xie, Qing Zhang, Jingfeng Mu, Weihua Yang   +7 more
doaj   +1 more source

Application of machine learning in the diagnostic work‐up of telomere biology disorders

HemaSphere, Volume 10, Issue 1, January 2026.
ABSTRACT We applied supervised and unsupervised machine learning (ML) analyses to a cohort of 140 patients referred to the Hematology Unit of the G. Gaslini Institute from 1989 to 2023 for persistent cytopenia and/or features suggestive of telomere biology disorders (TBDs). Patients were labeled as “TBD” (n = 20, established molecular diagnosis of TBD),
Erika Massaccesi, Luca Arcuri, Giacomo Cavalca, Fabian Beier, Lucia Vankann, Michela Lupia, Davide Cangelosi, Alice Grossi, Marina Lanciotti, Filomena Pierri, Francesca Fioredda, Maurizio Miano, Gianluca Dell'Orso, Maria Carla Giarratana, Daniela Guardo, Francesca Bagnasco, Sara Pestarino, Maria Binelli, Mareike Tometten, Robert Meyer, Fanny Frenzel, Domenico Coviello, Eugenia Mariani, Elena Palmisani, Saba Kainat, Isabella Ceccherini, Paolo Uva, Tim Henrik Brümmendorf, Carlo Dufour   +28 more
wiley   +1 more source

Therapeutic Targeting of the IGF Axis

Cells, 2019
The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease.
Eliot Osher, Valentine M. Macaulay
doaj   +1 more source

Titrating Rituximab to Circulating B‐Cells Starting From an Ultra‐Low Dose for Moderate‐to‐Severe Pemphigus

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Rituximab has been proven effective at a dose of 2 g in moderate‐to‐severe pemphigus by depleting CD20+B‐cell; however, studies have found that 100 mg RTX may suffice to fully suppress CD20+B‐cell. Objective We aimed at investigating the efficacy, safety, and prognostic factors of titrating RTX to circulating B‐cells starting from 100 mg ...
Rui Wang, Sai Wang, Panpan Shang, Xixue Chen, Ruoyu Li, Mingyue Wang, Suraiya Saleem   +6 more
wiley   +1 more source