Results 61 to 70 of about 3,956 (171)
Therapeutic Targeting of the IGF Axis
Cells, 2019 The insulin like growth factor (IGF) axis plays a fundamental role in normal growth and development, and when deregulated makes an important contribution to disease.
Eliot Osher, Valentine M. Macaulay
doaj +1 more source
Exploring tear fluid biomarkers and the ocular surface in thyroid eye disease
Acta Ophthalmologica, Volume 104, Issue 1, Page e28-e38, February 2026.Abstract Purpose To examine ocular surface changes and inflammatory tear fluid biomarkers in patients with thyroid eye disease (TED). Methods We included 106 Graves' disease (GD) patients (36 without TED, 32 with active and 38 with inactive TED) and 106 age‐ and sex‐matched healthy subjects for ophthalmological evaluation, including ocular surface ...
Mikael Thomassen Neset +13 more
wiley +1 more source
Immunomodulators in Graves’ ophthalmopathy: a systematic review
Frontiers in EndocrinologyBackgroundGraves’ Ophthalmopathy (GO), or thyroid eye disease, is an extrathyroidal complication of Graves’ disease, causing a significant impact on patients’ quality of life. There are consensus statements from both the American Thyroid Association (ATA)
Antoinette Yeung +10 more
doaj +1 more source
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
Advanced Science, Volume 13, Issue 4, 19 January 2026.This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang +16 more
wiley +1 more source
Advanced Science, Volume 13, Issue 4, 19 January 2026.An Allosteric Strategy for Thyroid Eye Disease This illustration depicts an aptamer (purple) binding to the target protein (white) at an allosteric site. This strategic binding induces a conformational change that acts as a shield, preventing pathogenic autoantibodies (red) from initiating the disease cascade, while leaving the protein's normal ...
Yanchen Zhang +16 more
wiley +1 more source
Application of machine learning in the diagnostic work‐up of telomere biology disorders
HemaSphere, Volume 10, Issue 1, January 2026.ABSTRACT We applied supervised and unsupervised machine learning (ML) analyses to a cohort of 140 patients referred to the Hematology Unit of the G. Gaslini Institute from 1989 to 2023 for persistent cytopenia and/or features suggestive of telomere biology disorders (TBDs). Patients were labeled as “TBD” (n = 20, established molecular diagnosis of TBD),
Erika Massaccesi +28 more
wiley +1 more source
Thyroid ophthalmopathy in hashimotos thyroiditis with hypothyroidism- an unusual presentation [PDF]
, 2015 Thyroid associated ophthalmopathy is an autoimmune disorder, most frequently encountered in hyperthyroid state, especially seen in Graves’ disease and is rarely associated with hypothyroidism.
Karnalli Jagannatha +3 more
core +1 more source
A Pruritic Predicament: An Unusual Presentation of Graves’ Disease Complicated by Pregnancy
Case Reports in Medicine, Volume 2026, Issue 1, 2026.Pruritus is a known but uncommon symptom of hyperthyroidism that can be misinterpreted or overlooked in a patient presentation. This is a case report of a 40‐year‐old female who presents with a 3‐month history of severe, worsening pruritus. Further history demonstrated potential signs of hyperthyroidism, and laboratory values demonstrated low TSH ...
Rob Lawless +4 more
wiley +1 more source
Graves' ophthalmopathy: interdisciplinary approach
, 2010 Graves' ophthalmopathy constitutes a major therapeutic challenge, so specialists of various disci-plines have to combine their forces. According to the last consensus of EUGOGO (European Group On Graves' Orbitopathy) the treatment of choice for Graves ...
core +1 more source
Exploring Thyrotoxic Hypercalcaemia Through Two Cases: A Myriad of Uncertainties
Case Reports in Endocrinology, Volume 2026, Issue 1, 2026.Hypercalcaemia is a recognised complication of thyrotoxicosis usually related to increased bone resorption. However, coexistent hyperphosphataemia is uncommon and may create diagnostic uncertainty. It is postulated that serum calcium and phosphate levels rise due to high bone turnover and increased renal reabsorption of phosphate in response to excess ...
Don Asiri Abeysiriwardana +4 more
wiley +1 more source