Results 131 to 140 of about 14,434 (161)
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The Role of Endorphins in Opiate Addiction, Opiate Withdrawal, and Recovery
Psychiatric Clinics of North America, 1983Substance abuse and addiction to various substances are enormous public health problems. Opiates are among the oldest drugs used and abused by humans. The authors trace the history of opiate use from Assyrian poppy art through modern times, and investigate the roles endorphins play in addiction, withdrawal, and recovery.
William S. Rea, Mark S. Gold
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Opiate Analgesia: Evidence for Mediation by a Subpopulation of Opiate Receptors
Science, 1980Naloxazone, a hydrazone derivative of the opiate antagonist naloxone, has a high affinity for opiate receptor binding sites. Naloxazone injections reduce opiate receptor binding to extensively washed mouse brain membranes for more than 24 hours, suggesting that the effect is irreversible.
Gavril W. Pasternak +2 more
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Opiate receptor binding—enhancement by opiate administration in vivo
Biochemical Pharmacology, 1976Abstract Administration of opiate agonists and antagonists to mice produces a dose-dependent 50–100 per cent enhancement of stereospecific [ 3 H]dihydromorphine or [ 3 H]naloxone binding to brain homogenates within 5 min. Three opiate antagonists are 10–1000 times more potent in eliciting this increase in binding than their structurally analogous ...
Candace B. Pert, Solomon H. Snyder
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2004
The term “opioid” applies to any substance, whether endogenous or synthetic, that produces morphine-like effects. Opiates are restricted to synthetic morphine-like drugs with non-peptidic structure. Opium is an extract of the juice of the poppy Papaver somniferum, which has been used socially and medicinally as early as 400 to 300 bc.
Seyed Adel Moallem +3 more
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The term “opioid” applies to any substance, whether endogenous or synthetic, that produces morphine-like effects. Opiates are restricted to synthetic morphine-like drugs with non-peptidic structure. Opium is an extract of the juice of the poppy Papaver somniferum, which has been used socially and medicinally as early as 400 to 300 bc.
Seyed Adel Moallem +3 more
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Perioperative opiate requirements in children with previous opiate infusion
Pediatric Anesthesia, 2011SummaryBackground: Critically ill children often require continuous opiate infusions. Tolerance may develop requiring a weaning strategy to prevent withdrawal symptoms. These children may also require subsequent surgical procedures. This is the first study to investigate whether previously opiate‐tolerant patients require higher doses of opiates for ...
Laura D. Cassidy +4 more
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Addiction, 1994
AbstractOpiate withdrawal is one of the longest studied and most well described withdrawal syndromes. Opiate withdrawal has been described as akin to a moderate to severe flu‐like illness. Opiate withdrawal is appropriately described as subjectively severe but objectively mild.
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AbstractOpiate withdrawal is one of the longest studied and most well described withdrawal syndromes. Opiate withdrawal has been described as akin to a moderate to severe flu‐like illness. Opiate withdrawal is appropriately described as subjectively severe but objectively mild.
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Addiction, 1994
AbstractOne of the greatest of challenges facing medicine is to devise effective and appropriate treatments for opiate problems. Such treatments are based on principles derived from the disciplines of pharmacology and psychology, but are also shaped by social issues and even by the views of practitioners.
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AbstractOne of the greatest of challenges facing medicine is to devise effective and appropriate treatments for opiate problems. Such treatments are based on principles derived from the disciplines of pharmacology and psychology, but are also shaped by social issues and even by the views of practitioners.
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Neurology, 1983