Results 61 to 70 of about 152,289 (375)

Assessing the Nature of Human Brain‐Derived Extracellular Vesicles on Synaptic Activity Via the Development of an Air‐liquid Microfluidic Platform

open access: yesAdvanced Science, EarlyView.
This seminal study highlights the interwoven and tightly regulated functions of brain‐derived extracellular vesicles. Using microfluidics, proteomics, and AI‐based electric signal analyses of cortical brain explants, this work provides a useful resource dataset revealing the composition of human brain‐derived extracellular vesicles obtained from ...
Corentin Bernou   +14 more
wiley   +1 more source

An analysis of patterns of distribution of buprenorphine in the United States using ARCOS, Medicaid, and Medicare databases

open access: yesPharmacology Research & Perspectives, 2023
Opioid overdose remains a problem in the United States despite pharmacotherapies, such as buprenorphine, in the treatment of opioid use disorder. This study characterized changes in buprenorphine use.
Zhi‐Shan Hsu   +8 more
doaj   +1 more source

Death by Dealer: When Addicts Overdose, Should Dealers Be Charged with Murder? [PDF]

open access: yes, 2015
The nation is currently in the throes of an epidemic of opiate addiction. More Americans now die from fatal opiate overdoses than from automobile accidents every year -- and the problem is especially pronounced in white suburban, exurban, and rural ...
Patrick Radden Keefe
core  

Effect of different agonistic experiences on behavioural seizures in fully amygdala kindled rats [PDF]

open access: yes, 1992
Fully amygdala kindled rats were exposed to two different inter-male agonistic experiences in order to study the interaction between epilepsy and acute social stress.
Beldhuis, Hans J.A.,   +2 more
core   +2 more sources

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside   +5 more
wiley   +1 more source

Opiate addiction in Republic of Srpska: Characteristics and etiology [PDF]

open access: yesSpecijalna Edukacija i Rehabilitacija, 2013
Opiate addiction is a significant social and health problem with a negative impact on individuals' health and their social environment. The aim of this paper is to analyze the characteristics of opiate addicts in order to determine the social and ...
Niškanović Jelena
doaj   +1 more source

Synthesis and Modification of Morphine and Codeine, Leading to Diverse Libraries with Improved Pain Relief Properties

open access: yesPharmaceutics, 2023
Morphine and codeine, two of the most common opioids, are widely used in the clinic for different types of pain. Morphine is one of the most potent agonists for the μ-opioid receptor, leading to the strongest analgesic effect.
Mona Kamelan Zargar Zarin   +3 more
doaj   +1 more source

Opiate Drug Seeking and Addiction: The Influence of Sucrose Consumption on the Acquisition and Expression of Morphine-induced Conditioned Place Preferences (CPP) [PDF]

open access: yes, 2019
Sucrose intake may lead to changes in brain and behavior similar to the effects of abused drugs. For example, sucrose may agonize endogenous opiate systems and modulate opiate-seeking behavior.
Bakner, Lee   +3 more
core   +1 more source

A Systematic Review of Substance Misuse Treatment Processes and Outcomes as Implemented in Prisons for Men in the UK

open access: yesCriminal Behaviour and Mental Health, EarlyView.
ABSTRACT Background With a rising prison population, a substantial portion of whom are identified as substance misusers, it is important to understand the availability of treatment pathways, their successes and areas for improvement. Given the likely importance of national factors in criminal justice and substance use service provision, we chose to ...
Kim Barnett   +9 more
wiley   +1 more source

Polysomnographic parameters as early as one week after detoxification could predict risk of relapse among detoxified opiates misuse patients over six months follow up period

open access: yesEuropean Psychiatry, 2021
Introduction Protracted abstinence syndrome represent group of attenuated psyc that lead to a persistant sense of discomfort among misuse patients after detoxification and may last for some months.Poor sleep in terms of duration and quality is one of ...
A. Rady, J. Mekky, A. Elsheshai
doaj   +1 more source

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