Neonatal abstinence syndrome: Pharmacologic strategies for the mother and infant. [PDF]
Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal opioid use is associated with numerous obstetrical and neonatal complications, this now has become a major public health problem.
Davis, Jonathan M.+2 more
core +2 more sources
Background: Coronavirus disease 2019 (COVID-19) is a severe acute respiratory syndrome that emerged in early December 2019. Global proliferation, abrupt increases in confirmed cases, and the risk of self-infection have caused significant stress and ...
Bijan Pirnia+5 more
doaj
Quality of life of treated opiate addicts in the methadone maintenance program and those treated with buprenorphine [PDF]
Background/Aim. Although the characteristics of the treatment are the most researched determinants of quality of life of opiate addicts, it is indisputable that there is a certain influence of the characteristics of addicts and addiction, too. The aim of
Marinković Mirjana+4 more
doaj +1 more source
Binding Pathway of Opiates to $μ$ Opioid Receptors Revealed by Unsupervised Machine Learning [PDF]
Many important analgesics relieve pain by binding to the $\mu$-Opioid Receptor ($\mu$OR), which makes the $\mu$OR among the most clinically relevant proteins of the G Protein Coupled Receptor (GPCR) family. Despite previous studies on the activation pathways of the GPCRs, the mechanism of opiate binding and the selectivity of $\mu$OR are largely ...
arxiv +1 more source
Targeted Learning on Variable Importance Measure for Heterogeneous Treatment Effect [PDF]
Quantifying the heterogeneity of treatment effect is important for understanding how a commercial product or medical treatment affects different subgroups in a population. Beyond the overall impact reflected parameters like the average treatment effect, the analysis of treatment effect heterogeneity further reveals details on the importance of ...
arxiv
Neurobehavioral consequences of chronic intrauterine opioid exposure in infants and preschool children: a systematic review and meta-analysis [PDF]
<b>Background</b><p></p> It is assumed within the accumulated literature that children born of pregnant opioid dependent mothers have impaired neurobehavioral function as a consequence of chronic intrauterine opioid use.<p>&
A Baldacchino+86 more
core +11 more sources
Dynamic modelling of hepatitis C virus transmission among people who inject drugs: a methodological review [PDF]
Equipment sharing among people who inject drugs (PWID) is a key risk factor in infection by hepatitis C virus (HCV). Both the effectiveness and cost-effectiveness of interventions aimed at reducing HCV transmission in this population (such as opioid ...
Cousien, Anthony+5 more
core +4 more sources
Selective review and commentary on emerging pharmacotherapies for opioid addiction. [PDF]
Pharmacotherapies for opioid addiction under active development in the US include lofexidine (primarily for managing withdrawal symptoms) and Probuphine®, a distinctive mode of delivering buprenorphine for six months, thus relieving patients, clinicians,
Ling, Walter+5 more
core +2 more sources
The increasing prevalence of illicit stimulant use among those in opioid treatment programs poses a significant risk to public health, stimulant users have the lowest rate of retention and poorest outcomes among those in addiction treatment, and current ...
Christopher S. Stauffer+8 more
doaj +1 more source
Sequential Deconfounding for Causal Inference with Unobserved Confounders [PDF]
Using observational data to estimate the effect of a treatment is a powerful tool for decision-making when randomized experiments are infeasible or costly. However, observational data often yields biased estimates of treatment effects, since treatment assignment can be confounded by unobserved variables.
arxiv